The CRISPR elements are part of a prokaryotic defence system directed against external attacks by e.g.viruses and may be viewed as a simple immune system of microorganisms. CRISPR是原核生物免疫防御系统的组成部分,能帮助原核生物抵抗入侵的病毒,可看作是一个简单的微生物免疫系统。
This blocking mechanism can, in principle, be "programmed" by incorporating into the CRISPR locus any desired A, T, G, C sequence that would match a target. 简要来说,这种阻断机制可以通过将需要的和目标基因互补的ATGC序列插入到CRISPR位点中来对其进行编程。
They also found that "CRISPR interference," as this phenomenon is known, involves the targeting of the incoming plasmid or virus DNA directly. 他们也发现了CRISPR干扰作用,正如被认识的一样,该作用包括间接将进入的质粒或者病毒DNA作为目标。
The Northwestern researchers have discovered that a special DNA sequence found in certain bacteria, called a CRISPR locus, can impede the spread of antibiotic resistance in pathogenic staphylococci. 西北大学研究人员在一种细菌中发现了一个叫做CRISPR位点的特殊DNA序列,该位点可以阻止抗生素抗性在致病性金黄色葡萄球菌中的传播。
Virtually any DNA molecule could be targeted with CRISPR interference. 事实上,任何一个DNA分子都可以被CRISPR干扰作用当成靶标。
The researchers'experiments show that the CRISPR locus limits the ability of the S.epidermidis strain to act as a plasmid recipient, essentially denying entry to the genes carrying the resistance. 研究者的实验表明,CRISPR位点限制了S。epidermidis菌株作为一个质粒接受体的能力,从本质上阻断了能引起抗性基因的进入。