Analysis of immunocompetence and expression of outer membrane protein ompA gene of Mycobacterium bovis 牛分枝杆菌外膜蛋白基因ompA的原核表达及免疫活性分析
Prokaryotic Expression of 42 KDa OmpA of RA Serotype 2 and Study of It's Immunocompetence 2型RA42KDa外膜蛋白的原核表达及免疫活性研究
The results suggest that the recombinant OmpA protein can be used as a vaccine candidate. 以上结果表明,重组OmpA蛋白可作为疫苗的候选抗原。
In addition, OmpA precursor aversion requires the SecA protein and corresponding energy metabolism. 此外,OmpA前体移位需要SecA蛋白来完成,且需要相应的能量代谢。
The hemolytic activity, protease activity and cytotoxicity of extracellular products in the ompA ⅱ mutant were significantly decreased. As well, the biofilm formation ability of the mutant strain was decreased. ompAⅡ基因缺失株胞外产物溶血活性、溶蛋白活性及细胞毒性均有明显降低,生物被膜的形成能力也有所下降。
But no report on immunogenicity and immunoprotection of OmpA has been seen. 但有关OmpA的免疫原性和免疫保护作用的研究未见报导。