Immunosuppression mediated by TLR was dependent on the production of immunosuppressive kynurenines by the tryptophan-degrading enzyme indoleamine-2,3-dioxygenase-1 ( IDO1). TLR介导的免疫抑制反应不依赖于色氨酸代谢酶吲哚胺2,3加双氧酶1(IDO1)产生的免疫抑制物质犬尿氨酸。
The light reaches the film of a camera through the lens. It leaves the air and goes into the glass; then it bends. With a tlr you can see through a mirror exactly what you is go to record. 光通过镜头投射到照相机的胶卷上,它穿过空气进入镜头就会发生折射。用双镜头反射相机,你可以通过一面镜子直接看到你拍下来的画面。
The involvement of TLR-mediated pathways in autoimmune and inflammatory diseases has been. 研究人员已经提出对自体免疫与炎症性疾病中TLR介导的通路进行深入研究。
With a tlr you can see through a mirror exactly what you is go to record. 用双镜头反射相机,你可以通过一面镜子直接看到你拍下来的画面。
Effect of astragalus on expression of TLR_4/ MyD88 in human renal tubular cells induced by serum of asphyxia neonatorum 黄芪对新生儿窒息后血清诱导人肾小管细胞TLR4/MyD88表达的影响
Up-regulatory Effect of Peptidoglycan on the Expressions of TLR_3 and TLR_9 mRNA in Human Basophils 革兰阳性菌肽聚糖对人嗜碱性粒细胞中TLR3、TLR9mRNA的上调作用
Significance and expression of TLR_4, Caspase-3 and Fas in gastric cancer and gastric ulcer TLR4、Caspase-3和Fas在胃癌、胃溃疡中的表达及意义
Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis 单核细胞对原发性胆汁性肝硬化患者体内特定的TLR配体反应性的改变
The non-time-lock response ( N-TLR) and time-lock response ( TLR) of 73 unit discharges in somatosensory cortex evoked by nociceptive stimulation of peripheral nerve ( P-ED) were analysed quantitatively with micro-computer and compared each other. 应用微机对刺激外周神经诱发体感皮层单位放电(P-ED)的时锁反应(TLR)和非时锁反应(N-TLR)进行定量分析,互相比较。
Conclusion That TLR2 and TLR4 both expressed in human urinary tract epithelium is probably associated with the distribution of uropathogenic bacteria. 结论人尿路上皮细胞中TLR2和TLR4均有表达,尿路感染致病菌分布量可能与TLR亚型表达情况有关。
Conclusion: TLR can obviously improve sciatic nerve function and ameliorate morphology changes in rats with diabetic peripheral neuropathy, probably through depleting free radical production, improving endothelial cell function and ameliorating hemorheology changes. 结论通络方剂可明显改善糖尿病大鼠坐骨神经功能和结构,其机制可能是通过减少自由基生成,改善内皮细胞功能和血液流变学变化。
C-type lectin receptors ( CLR), which play an important role in the immune response, are a new family of pattern recognition receptors. C型凝集素受体(CLR)是模式识别受体家族中有别于TLR的新家族,在机体免疫应答中发挥着重要作用。
Recently, with the discovery of the Toll-like receptors ( TLR), the role of innate immune responses in the control of adaptive immunity has become a new area of interest. 随着Toll样受体(TLR)的发现,固有免疫应答如何调控适应性免疫应答已成为研究的热点。
TLR can regulate both innate immunity and adaptive immunity in molecule level.TLR2 and TLR4 are two important molecules to the anti-infection immunity to M.tuberculosis. 研究表明,TLR对先天免疫和获得性免疫都有调控作用,与抗结核感染免疫有关的主要是TLR2和TLR4。
Toll like receptor ( TLR) belong to animal pattern recognition receptor family. Toll样受体(TLR)蛋白家族属于动物模式识别受体家族。
Objective To investigate the effect of nitric oxide on Toll-like receptors ( TLR) 2/ 4 expression in the lung of rats with acute hemorrhagic necrotizing pancreatitis ( AHNP). 目的研究一氧化氮(NO)对急性出血坏死性胰腺炎(AHNP)肺组织Toll样受体(TLR)2/4表达的影响。
Objective To study the interaction between Toll-like receptor ( TLR) 4 and myeloid differentiation protein-2 ( MD-2) in living cells using fluorescence resonance energy transfer ( FRET) technology. 目的利用荧光共振能量转移(FRET)技术在活体细胞研究人Toll样受体(TLR)4与髓样细胞分化蛋白2(MD-2)的相互作用。
The results showed that the relationship between the N-TLR and TLR of P-ED was rather complicated. 结果表明TLR和N-TLR的关系比较复杂,两者反映不同信息,TLR可能反映更多信息。
There was one patient underwent TLR in the SES group. SES组有1例患者进行了靶病变血运重建。
Objective To study the mRNA expression of Toll-like receptor ( TLR) 2 and 4 in human urinary tract epithelium. 目的探讨Toll样受体(Toll-likereceptor,TLR)2和4在人尿路上皮细胞中的表达情况。
However, the overexpression and activation of TLR will lead to severe immune dysfunction. 然而TLR的过度表达及活化将导致严重的机体免疫功能紊乱。
Toll-like receptor ( Toll-like receptors, TLR) which can recognize pathogens and activate the immune response, is an important class of pattern recognition molecules involved in the innate immunity of the body, is also connected to the innate and acquired immunity bridge. Toll样受体(Toll-Likereceptors,TLR)可以识别病原体并激活免疫反应,是参与机体先天免疫的一类重要模式识别分子,也是连接先天免疫和获得性免疫的桥梁。
TRLs regulate the acquired immune though up-regulating Antigen-presenting cell surface costimulatory molecules and antigen-presenting cells to secrete cytokines which could induce the differentiation of T and B lymphocytes to the effects of T and B lymphocyte. TLR样受体通过上调抗原递呈细胞表面的共刺激分子及抗原递呈细胞分泌的细胞因子,诱导T和B淋巴细胞向效应T和B淋巴细胞分化,进而调节获得性免疫。
The specificity of TLR signaling depends on the action of different TIR domain-containing adaptor proteins. 不同TLR信号通路的特异性依赖于受体募集不同的包含TIR结构域的适配分子。
Recent data have demonstrated that mammalian Toll-like receptors ( TLRs) participate in intracellular signaling initiated by endotoxin/ LPS. 最近有资料显示哺乳动物Toll样受体(toll-Likereceptors,TLR)参与了由内毒素或其他病原体诱导的细胞内信号转导,其中最关键的是TLR2和TLR4分子。
But the research about TLR is more concentrated in mammals, while the molecular mechanism of amphibians is unclear. 但目前对TLR的研究多集中在哺乳动物,两栖动物中该分子的作用机制尚不明确。
Amphibians skin as the tissue of directing contact with pathogenic microorganisms in their habitats, formed the first natural defense system against pathogenic microorganisms in the process of natural evolution, while TLR molecules have an important role in innate immune defense process. 皮肤作为两栖类动物与其栖息环境中的微生物直接接触的组织,在自然进化过程中形成了抵御病原微生物的第一道天然防御系统,而TLR分子在其先天免疫防御过程中具有十分重要的作用。
Toll-like receptor 4 ( Toll like receptor 4, TLR4) as the earliest discovered Toll-like receptor ( TLR) subtype is one of the natural immune system to identify the main pathogenic microorganisms receptors. Toll样受体4(tolllikereceptor4,TLR4)作为发现最早的To11样受体(TLR)亚型之一,是天然免疫系统识别病原微生物的主要受体。
Toll-like receptor ( TLR) 4, an important member of PRR, is expressed mainly by microglia, and plays important role in innate immune reaction in the CNS. TLR4是PRR的一个重要成员,在CNS主要表达在小胶质细胞,且在CNS固有免疫和适应性免疫应答的启动中扮演重要的角色。