acanthosis

1. Pathological changes of the organization, mainly the epidermal cuticle significant parakeratosis, acanthosis cell layer thickening, epidermal sudden downward extension of in-depth dermis.
   本型组织病理改变，主要是表皮角质层有显著角化不全，棘细胞层增厚，表皮突向下延展，深入真皮。
2. Objective To explore the high risk factors of metabolic syndrome ( MS) in obese children with acanthosis nigricans.
   目的探讨肥胖伴黑棘皮病儿童代谢综合征（MS）的高危因素。
3. A Case of Malignant Acanthosis Nigricans Associated with Lung Cancer
   恶性黑棘皮病伴发肺癌1例
4. Acanthosis nigricans in a plaque of scleredema on the back of a diabetic patient: A case report
   发生于糖尿病患者背部硬皮病斑块处的黑棘皮病：1例报道
5. Two cases of unilateral nevoid acanthosis nigricans are reported.
   报告2例具有黑棘皮病表现的表皮痣。
6. The 1st case suffered from non-insulin-dependent diabetes mellitus ( NIDDM), These 8 patients presented irregular menses, hirsutism, acne or obesity with acanthosis nigricans.
   1例同时并存非胰岛素依赖型糖尿病（NIDDM）。8例患儿皆有月经失调、多毛、痤疮，4例肥胖者示黑棘皮的临床特征。
7. Association of acanthosis nigricans with insulin resistance and adipocytokine in children with simple obese
   单纯性肥胖儿童黑色棘皮症与胰岛素抵抗性及细胞因子的关系
8. AIM: To observe the characteristics of glycometabolism in moderate to severe corpulent children with acanthosis nigricans and the effects of metformin in interfering treatment of glycometabolism and lipometabolism.
   目的：观察中、重度肥胖伴黑棘皮病病儿的糖代谢特征，二甲双胍干预治疗对糖、脂代谢的影响。
9. A case of hyperandrogenism, insulin resistance and acanthosis nigricans syndrome
   高雄激素血症-胰岛素抵抗-黑棘皮病综合征1例
10. A family presenting 3 cases of benign acanthosis nigricans
    一家三例良性黑棘皮病报告
11. Obese children with benign acanthosis nigricans and insulin resistance: analysis of 19 cases
    肥胖儿童伴良性黑棘皮病与胰岛素抵抗19例分析
12. Conclusion Children with benign acanthosis nigricans are closely associated with obesity, hyperinsulinemia, insulin resistance, and are at high risk of developing type 2 diabetes mellitus.
    结论儿童假性黑棘皮病与肥胖、高胰岛素血症、胰岛素抵抗密切相关，是发生2型糖尿病的高危人群。
13. Pathological changes of the abdomen showed hyperkeratosis and mild irregular acanthosis, the granular layer was thin and melanophage and perivascular lymphocytic infiltration in upper dermis.
    腹部皮损组织病理学检查示，表皮角化过度，颗粒层变薄，棘层不规则增厚，真皮浅层散在噬色素细胞，血管周围有淋巴细胞浸润。
14. The Levels of Plasma Insulin and Erythrocyte Insulin Receptors in Children with Acanthosis Nigricans Associated with Obesity
    肥胖儿童良性黑棘皮病患者血中胰岛素及红细胞胰岛素受体的测定
15. Clinical significance of pancreatic β-cell function in obese children with acanthosis nigricans
    肥胖伴黑色棘皮病儿童胰岛分泌功能的临床研究
16. The novel mutations in exon 17 of insulin receptor gene in patients with acanthosis nigricans and their close relatives
    胰岛素受体基因17外显子点突变的测得
17. Epidermal changes consist of acanthosis, vacuolar degeneration, parakeratosis, hyperkeratosis and necrosis.
    上皮的变化包括棘细胞增生，空泡变性，不全角化，过度角化和坏死等。
18. Detection of mutations in the kinase domain of insulin receptor in patients with acanthosis nigricans
    胰岛素受体基因突变的研究
19. Histologically, LP shows hyperkeratosis, focal hypergranulosis, acanthosis, typical liquefaction degeneration of basal cells and band-like inflammatory infiltrate predominantly of T cells in the upper dermis.
    LP组织病理学有特征性改变，可见表皮角化过度，颗粒层楔形增厚，棘细胞层不规则增厚，基底细胞液化变性和真皮浅层以淋巴细胞为主的带状浸润。
20. Results The basic histological characteristics of seborrheic keratosis were hyperkeratosis, acanthosis, papillomatosis and that the inferior end of tumor was paralled to normal epidermis.
    结果脂溢性角化病的基本病理特征为角化过度、棘层肥厚、乳头状瘤样增生，肿瘤的下端与正常表皮平行。
21. Results Two of 42 obese children with benign acanthosis nigricans were diagnosed as type 2 diabetes mellitus.
    结果假性黑棘皮病组有2例诊断为2型糖尿病，21例糖耐量异常，明显高于单纯肥胖儿童组；
22. A Case of Acanthosis Nigricans Associated with Alimentary Canal Adenocarcinoma
    黑棘皮病伴发消化道低分化腺癌1例
23. With persistent anovulation, androgen excess and insulin resistance as the main feature, less clinical and more performance for the period or amenorrhea, infertility, hirsutism, obesity, acanthosis nigricans psychosis.
    以持续性无排卵、雄激素过多和胰岛素抵抗为主要特征，临床多表现为月经量少或闭经、不孕、多毛、肥胖、黑棘皮症等。
24. Metabolic manifestations of FPLD include hypertriglyceridemia, depressed HDL cholesterol, dysglycemia, acanthosis nigricans, and, among women, hirsutism, polycystic ovary syndrome ( PCOS), and menstrual irregularities.
    代谢方面的异常包括高甘油三酯血症、低高密度脂蛋白（HDL）、糖代谢异常、黑棘皮症，女性患者存在多毛症、多囊卵巢综合症（PCOS）、月经紊乱。
25. In some cases, the rashes are the first signs of an underlying disorder. Such as malignant acanthosis nigricans, which can occurring several months or years before gastric cancer, and the dermatomyositis, which the skin lesions often occurring before the muscle lesions.
    在某些疾病中，皮疹可作为系统性疾病的首发信号，比如，恶性黑棘皮病可在胃癌发生前的数月或数年出现；皮肌炎的皮肤损害早于肌肉的病变。

noun

1. an abnormal but benign thickening of the prickle-cell layer of the skin (as in psoriasis)