Objective: Gsp oncogenes are the cause of pituitary tumor development in some acromegalics. They are the result of point mutation within the gene coding for the alpha subunit of the Gs protein and they cause constitutive cAMP production. gsp癌基因是肢端肥大症患者发生垂体肿瘤的重要原因,这是由于编码刺激性G蛋白α亚基(Gsα)的基因存在突变,导致细胞内cAMP水平持速升高所致。