In addition, Actos ( pioglitazone), a drug used to treat diabetes, also improved many features of NASH but was associated with weight gain. 另外,一种用于治疗糖尿病的药物Actos(匹格列酮)也可改善NASH的很多症状,但会导致肥胖。
Nissen says that the study was not designed to determine whether Actos actually cuts the risk of heart attacks and stroke, but he thinks it "will translate into clinical benefits down the road." Nissen说这项研究设计并不是旨在确定艾可拓是否确实降低心血管事件和中风的危险性,但他认为这种益处“接下来一定会带来更好的临床效益。”
About half were given Actos, a member of a relatively new class of antidiabetic agents known as thiazolidinediones. 约一半给予艾可拓,一种新型的抗糖尿病药物,噻唑烷二酮类。
Takeda said following the panel decision that the company underscored its position that Actos offers a proven safety profile. 武田公司表示理解顾问团的决定,公司强调了其立场,艾可拓的安全性方面业经证实。
The study was funded by Takeda Pharmaceuticals, which manufactures Actos. 该研究由生产艾可拓的武田制药赞助。
Researchers reported that vitamin E and Actos helped certain patients with NASH. 试验持续了96周,研究者报告了维生素E和Actos对一些病人有效。
Vitamin E functions as an anti-oxidant while Actos improves the sensitivity of cells to insulin, a hormone that controls sugar and fat metabolism. 维生素E起到抗氧化的作用,而Actos改善了细胞对胰岛素的敏感程度,胰岛素正是控制糖和脂肪代谢的关键激素。
In July, FDA halted enrollment in new clinical trials that would compare the health risks of Avandia with those of Actos, a competing drug by Takeda Pharmaceuticals. 在七月,FDA停止了一项比较文迪雅和Actos(Takeda药业的一种竞争药物)心脏病风险的新临床试验的征召工作。
In a briefing document on the Aandia meeting, FDA officials noted that "it is also important to place any risk into context* of other aailable therapies," and that could gie another boost to Actos. 在文迪雅会议上的一份简要文件中,FDA官员指出“审查其他疗法的风险同样重要”,这也将促进Actos的推广。
Actos carries a "black box" warning that the drug may trigger heart failure, but it has not been linked to any increased risk of heart attack. 艾可拓背着一个“黑锅”,警告这种药物可能引起心衰,但是到目前为止并未发现它增加心脏事件的危险性。
But the company has stressed that INT131 does not agonize the full receptor and therefore does not turn on the genes associated with weight gain and edema, as seen with Avandia and Actos. 但公司强调,INT131不会激发所有的受体,因此不会启动增重或水肿相关的基因,不同于文迪雅和Actos。
Results showed that Actos halted the dangerous progression of atherosclerosis and even started to reverse it, Nissen says. Nissen说,结果证实艾可拓阻止动脉粥样硬化的发展并甚至开始逆转这种趋势。
These early results showed no overall association between Actos exposure and risk of bladder cancer. 这些早期的结果显示吡格列酮应用与膀胱癌风险之间没有总体的联系。
But on Monday morning, two other major studies came out with findings showing that Avandia increased the risk of cardiovascular trouble when compared to both a placebo and to Actos. 但周一上午,另两项已完成得研究显示,相对于安慰剂和Actos,文迪雅增加了患者心血管不良反应的风险。