Effect of high glucose on intercellular adherens junction complex in cultured human peritoneal cells in vitro 高糖对人腹膜间皮细胞间粘合连接复合体的影响
Polymorphonuclears induce phosphorylation of adherens junction proteins and hyperpermeability in capillary vascular endothelial cells 多形核白细胞导致血管内皮细胞粘附蛋白磷酸化和通透性增高
Objective: To investigate the effect of the high glucose concentration on the intercellular adherens junction complex in the cultured human peritoneal mesothelial cells ( HPMC), and clarify the cause of decreased dialysis efficiency during prolonged peritoneal dialysis. 目的:研究高糖对人腹膜间皮细胞(HPMC)间粘合连接复合体表达的影响,探讨腹膜透析(PD)中腹膜间皮层完整性损伤的机制。
Aprotinin could downgrade the expression of ICAM-1 of TNF α activating endothelial cells and prevent the loss of β-catenin of the cells, protect the adherens junctions of endothelials cells. 抑肽酶可抑制TNFα活化的人脐静脉内皮细胞ICAM-1的表达,可避免β-catenin的丢失。
Epithelial and endothelial cells can form selective barriers between tissues and different body compartments. They polarize and adhere to each other through intercellular complexes including tight junctions ( TJs), adherens junctions and desmosomes. 上皮细胞和内皮细胞在组织和不同的细胞间形成了选择性的屏障,它们发生了极化,且通过细胞间的复合物互相连接,这些复合物包括紧密连接、粘性连接和桥粒。
One is as a structural component of adherens junction, which forms the cadherin-catenin complex to mediate intercellular adhesion. The other is as a downstream effector of Wnt signaling pathway, which controls essential steps in many aspects of embryogenesis and tumorigenesis. 一是作为附着连接的组成部分,与钙粘蛋白结合形成复合体参与细胞间连接;二是作为信号分子,是Wnt信号途径的重要环节,在胚胎发育和肿瘤发生中起重要作用。