To limit the chance of resistance emerging, the WHO recommends combining artesunate with other drugs, mainly amodiaquine ( see WHO warns against misuse of key malaria drug). 为了减少耐药性出现的可能性,世界卫生组织推荐将青蒿琥酯与其它药物联合使用,特别是与阿莫地喹(参见世界卫生组织警告不要误用关键抗疟药物)。
Technical note: The medicine sent to Niger is artesunate+ amodiaquine, one of four artemisinin-based combination therapies ( ACTs) recommended by WHO. 技术说明:发运到尼日尔的药物系世卫组织建议的四种以青蒿素为基础的联合治疗药物之一:青蒿琥酯+阿莫地喹。
Methods The amodiaquine concentration in plasma through aether extraction was determined by HPLC-MS, and its pharmacokinetic parameters were calculated. 方法血浆样品经乙醚萃取后,用HPLC-MS测定血浆中阿莫地喹的浓度并计算药代动力学参数。
RESULTS: Except for the absence of resistance to mefloquine and quinine, the resistance rate of the parasite to chloroquine, amodiaquine and piperaquine was 84 6%, 86 1% and 38 0% respectively. 结果:甲氟喹和奎宁分别测定36例和33例,未发现抗性病例。氯喹、氨酚喹和哌喹抗性率分别为84.6%、86.1%和38.0%。
CONCLUSION: This HPLC method is simple, sensitive and suitable for pharmacokinetic study of amodiaquine. 结论:该法简单,灵敏适合于阿莫地喹的药动学研究。
CONCLUSION: Among the antimalarials tested in Hainan and Yunnan, high resistance of P.falciparum to chloroquine, amodiaquine and piperaquine was found. 结论:云南和海南两省恶性疟原虫对氯喹、氨酚喹和哌喹有高度抗性,但停用氯喹后,恶性疟原虫对氯喹敏感性有所恢复。
Efficacy of amodiaquine, Fansidar and their combination in the treatment of chloroquine-resistant falciparum malaria 氨酚喹、法西达及其复方治疗抗氯喹恶性疟的效果
The two resistant lines did not show cross resistance to chloroquine, primaquine and amodiaquine. 两抗性虫系对氯喹、伯喹及氨酚喹无交叉抗药性。
Synthesis of trifluoromethyl amodiaquine analogs and antimalarial activity 三氟甲基氨酚喹类似物的合成及其抗疟活性
Susceptibility of Plasmodium falciparum to chloroquine, piperaquine, amodiaquine, mefloquine and quinine with in vitro microtechnique in Hainan Island 应用体外微量法测定海南岛恶性疟原虫对氯喹、喹哌、氨酚喹、甲氟喹及奎宁的敏感性