Objective: To observe the changes of fentanyl pharmacokinetics in rats during anhepatic phase by treatment of large dose of dexamethasone and to investigate the extrahepatic metabolism of fentanyl. 目的:研究大剂量地塞米松处理后大鼠无肝期药代动力学的影响,探讨芬太尼的肝外代谢及地塞米松对其盰外代谢的影响。
The total blood loss and blood loss during preanhepatic, anhepatic and anhepatic phase was calculated by calculation method. 分别用计算法统计每个患者无肝前期、无肝期、新肝期的出血量和总的出血量。
Methods: To12 cases of experimental pig OLT, we observed the changes of endotoxin levels and treated them using blood perfusion during anhepatic period. 方法进行实验性猪OLT术式12例,术中对内毒素血症进行观察并采用无肝期血液灌流治疗。
Subdivision and capacity management of anhepatic phase in Piggy-back liver transplantation 背驮式肝移植无肝期的细分与容量管理对策
Conclusions: Decreasing the operation time and stability of hemodynamics in anhepatic phase are the keys for success in OLTs without VVB. 结论:手术中无肝期时间的缩短及血流动力学的相对稳定是非转流条件下猪原位肝移植成功的关键。
Results The time for dissociating the recipient's liver and that of anhepatic phase were significantly longer and the volume of intraoperative bleeding, intraoperative blood transfusion and dosage of hemostatic drug markedly higher in group A than in group B.Two patients of group A died postoperatively. 结果A组术中病肝游离时间、无肝期时间明显较B组长,出血、输血量及止血药物的用量均明显大于B组,手术死亡2例均为A组病例。
A Clinical Study of the Renal& Intestinal Injury at the Anhepatic Phase of Non-bypass Liver Transplantation Operation 非转流肝移植无肝期对肾脏和小肠损伤的临床与实验研究
Objective: To investigate pharmacokinetics of propofol during anhepatic period of orthotopic liver transplantation ( OLT) in children. 目的:研究小儿肝移植无肝期丙泊酚的药代动力学特征。
Arterial pH and BE declined during anhepatic phase. 动脉血酸碱度(pH)和剩余碱(BE)于无肝期有所下降。
With logistic regression analysis, it was revealed that CTP score, volume of blood loss, and duration of anhepatic phase and low blood pressure were risk factors for development of acute renal failure. 应用Logistic回归分析筛选后保留的危险因素包括CTP评分、无肝期时间、出血量和低血压持续时间。
DO_2, VO_2 and CjvO_2 were decreased during anhepatic phase; 无肝期DO2、VO2、CjvO2降低,其余时期DO2升高,术毕VO2升高;
Venous blood samples were taken and urine was collected during anhepatic phase for determination of serum creatinine ( Cr) concentration and creatinine clearance ratio ( CCr) was calculated. 观察无肝期输液量、血液动力学和尿量,检测血清肌酐(Cr)和肌酐清除率(CCr)。
Experimental study of rat orthotopic liver transplantation: anesthesia and infusion in anhepatic period 大鼠肝移植麻醉与无肝期补液的研究
Changes of fentanyl pharmacokinetics in rats during anhepatic phase by treatment of large dose of dexamethasone 大剂量地塞米松对大鼠无肝期芬太尼药代动力学的影响
Conclusions ( 1) The key of establishing successful models include high quality donor liver, practiced microsurgical techniques and short anhepatic phase. 结论(1)成功建立大鼠原位肝移植模型的关键在于完善的手术技术,主要包括高质量的供肝获取、熟练的显微血管吻合技术和尽量短的无肝期。
Cannulation was adopted to inosculate the hepatocystic duct, and the management during peri-operation period was enhanced so as to maintain the blood pressure in a satisfactory level during the anhepatic phase. 在非体外静脉转流的条件下行同种异体原位肝移植术,严格控制动物无肝期时间,应用套管法吻合胆总管,另外加强围手术期的处理,使无肝期的血压维持在满意水平。
Amongst these 36, 17 died from primary graft non-function, 4 anesthesia, 3 prolongation of anhepatic phase and 12 grafted liver bleeding after reperfusion. 而NHBD组术后近期共有36只受体分别死于原发性移植肝无功能(17)、麻醉过深(4)、无肝期较长(3)和供肝再灌注后渗血(12)。
Conclusions Venovenous bypass could improve hemodynamic and metabolic stability in the anhepatic phase, but it also could increase operation duration, liver ischemic time and cost. 结论体外静脉静脉转流可以使肝移植手术无肝期的血液循环动力学和代谢处于相对稳定状态,但也存在增加手术和肝缺血时间、增加费用等一些问题。
CONCLUSION: Using magnetic rings for large vascular reconstruction in canine liver transplantation is simple, and the anhepatic phase is shortened obviously. 结论:使用磁环进行犬肝移植大血管重建,吻合过程简便,无肝期明显缩短。
Pharmacokinetic characters of sufentanil during anhepatic period of liver transplantation 肝移植无肝期舒芬太尼的药代动力学特点
Conclusions: It is important for successful operation with sophisticated microsurgical technique, effectively modified measure and attention for operation details. Well perfusion, shortened anhepatic phase of recipient and hepatic artery reconstruction in transplanted liver can increase the stability of animal model. 结论:娴熟的显微外科技术、有效改良措施和注重手术细节是手术成功的保障,良好的灌注、受体无肝期的缩短及重建移植肝脏动脉血供能有效提高动物模型的稳定性。
Conclusion: The modified cuff technique possesses advantages of short anhepatic phase, high operative successful rate, and long survival time after surgical operation, which is an ideal operative method of orthotopic liver transplantation in the rat. 结论:改进的二袖套法大鼠原位肝移植具有无肝期短、手术成功率高、大鼠术后存活时间长的优点,是大鼠原位肝移植的理想术式。
Methods: 21 end-stage liver disease patients received liver transplantation. Veno-venous bypass was performed during anhepatic phase. BP, HR, CO, CI and CVP were measured at different time points of early anhepatic phase and early reperfusion phase. 方法:21例终末肝病病人接受肝移植手术,无肝期采用体外静脉静脉转流,观察无肝早期和新肝早期不同时间点的BP、HR、CO、CI和CVP值。
Methods Male Sprague Dawley rats were used as donors and recipients of orthotopic liver transplantation, the cold ischemia period and anhepatic phase was 120 min and 16~ 20 min respectively. 方法采用SD大鼠建立原位肝移植动物模型,供肝冷缺血期为120min,受体无肝期16~20min。
There was no significant difference between NS group and Tau group in the duration of operation, cold-ischemia time, anhepatic phase time and loss of blood. NS组和Tau组两组间手术时间、供肝冷保存时间、受体无肝期时间相比无显著差异。
Clamping infrahepatic vena cava, hepatic artery and portal vein can maintain the liver no-blood state after perfusion during anhepatic phase. 2. 结论1.阻断肝卜卜腔静脉、肝动脉和门静脉能保持灌注后肝脏无肝期内的无血状态。
Key factors for successful operation include right liver infusion methods, rigorous peritoneal hemostasis 、 skilled microvessel suture technique, shortened anhepatic time, improved fluid therapy, corrected acid and alkali balance during operation and rewarming after operation. 正确的供肝灌注、严密的腹腔止血、熟练的显微血管缝合技术、尽量缩短的无肝期、完善的术中补液纠酸及术后复温是保证手术成功的关键。