antiplasmin

英

美

n. 抗（血）纤维蛋白酶；抗（血）纤维蛋白溶素

AIM: To prepare monoclonal antibodies ( mAbs) against human plasmin α 2 antiplasmin complexes ( PAP).
目的：制备纤溶酶α2抗纤溶酶复合物（PAP）的单克隆抗体（mAb）。
Results Plasma tissue plasminogen activator activity and D dimer ( D D) were significantly elevated at diagnosis, while the plasminogen ( PLG), α 2 antiplasmin(α 2 PI) and plasminogen activator inhibitor ( PAI) activity decreased.
结果患者血浆组织纤溶酶原激活物活性、D-二聚体（D-D）水平显著升高；纤溶酶原活性（PLG）、α2抗纤溶酶活性（α2-PI）、纤溶酶原激活抑制物活性（PAI）水平降低；
CONCLUSION: The mAbs against PAP neoantigens with high affinity was acquired successfully, which provided a tool for determination of plasma levels of PAP without interferences from plasminogen and α 2 antiplasmin and for research on fibrinolytic status in vitro.
结论：成功地制备针对PAP新抗原的具有高亲和力的mAb，为建立不受其前体分子干扰的PAP特异性检测方法，研究纤溶系统的激活状态提供了工具。
Kinetics Study on Antiplasmin Activity of Recombinant TFPI-2 in Vitro
重组TFPI-2抑制纤溶酶活性的酶促动力学实验方法研究