Oligonucleotides have the ability to selectively block target gene and mRNA according to base-pair complementary binding at the process of replication and transcription of DNA, cutting, transfer or translation of mRNA, and thereby may become the kind of perfect therapeutic agents at genetic level. 寡核苷酸可根据碱基互补原则特异性地与靶基因或mRNA结合,从基因复制、转录、mRNA剪接、转运或转译等水平上抑制目的基因的表达,从而实现基因调控。
Empirical rules, which take into account the non-neighbor interactions between the base-pair steps, have been presented to predict DNA curvature. 考虑到碱基对梯阶间的非紧邻相互作用,提出DNA宏观弯曲的经验预测规则。