Some individuals have harmful side effects with long-term use of bisphosphonates, the current main class of osteoporosis treatment drugs. 有些患者长期使用双膦酸盐会产生有害的副作用,它是目前治疗骨质疏松症的主流药物。
The Mayo Clinic team provided recommendations for the myeloma patients for whom bisphosphonates are indicated. 梅奥诊所给二膦酸盐化合物已经明确的骨髓瘤患者提供建议。
Conclusion bonin, as a safe and effective bisphosphonates preparation, could relieve bone pain in multiple myeloma more effectively when combined with chemotherapy. 结论博宁是一种安全有效的双膦酸盐制剂,与化疗联合应用可以显著缓解多发性骨髓瘤患者的骨痛。
Bisphosphonates Osteoporosis Sickness Treatment Medicine Research Survey 二膦酸盐类药物治疗骨质疏松症的研究概况
Bisphosphonates are effective in treatment and prevention of cancer treatment-induced bone loss, but their value in the prevention of fractures is still investigational. 二磷酸盐化合物对于肿瘤的预防和治疗相关性骨事件的发生是有效的,但其对肿瘤相关骨折的预防价值仍处于研究中。
Bisphosphonates may modestly affect clinical disease activity in ankylosing spondylitis. 二磷酸盐可能对强直性脊柱炎的临床疾病有轻微影响。
Our aim was to evaluate the fracture rate in breast cancer patients receiving adjuvant bisphosphonates compared with those receiving no treatment or placebo. 本研究用于评价乳腺癌患者接受辅助性二磷酸盐化合物组对比安慰剂组的骨折发生率情况。
Treatment of Ankylosing Spondylitis with Bisphosphonates: Mechanisms and Effects 二膦酸盐治疗强直性脊柱炎的疗效和机制
This paper reviewed the study about reducing the number of wear debris, preventing access of the particles to the bone implant interface and using of bisphosphonates. 本文对近年来为减少磨损微粒的产生、阻止微粒进入假体骨界面和向远端移动、应用二膦酸盐等的研究作一综述。
Clinical Practice Progress of Bisphosphonates in Bone Surgery 二膦酸盐类药物在骨外科中的临床应用进展
She picked the drugs because of studies in humans that suggest bisphosphonates may help prevent cancer from spreading to the bone. 她之所以选择这些药物是因为在人类研究中表明双磷酸盐可以帮助阻止癌症扩散到骨骼。
Clinical Observation of Radiotherapy on Metastatic Bone Pain with Cancer Clinical study of bisphosphonates in relieving bone pain in malignant tumor patients with bone metastasis 放射治疗癌性骨转移疼痛的临床研究
Bisphosphonates are synthetic equivalents of naturally-occurring pyrophosphate, which inhibits bone resorption and aids the body in eliminating excess calcium. 二膦酸盐化合物是人工合成的体内自然存在的焦磷酸盐的等价物,它可以抑制骨再吸收作用、帮助体内多欲钙的排除。
Impact of Stainless Steel Screws Coated with Bisphosphonates on Bone 带二膦酸盐涂层的不锈钢螺钉对周围骨的影响
Scientists say the value of bisphosphonates has now been clearly proven, and it would be unethical to do another study in which the drug is withheld from some participants. 科学家们认为双膦酸盐的疗效目前已被确证,在下一次的试验中,对于一些受试者不给予Reclast是不道德的。
Separation and Analysis of Bisphosphonates by Reverse Phase High-performance Liquid Chromatography; Climates can be classified from different stand point, because the term is rather complex. 双膦酸类药物反相液相色谱分离与应用研究因为气候这个名词相当笼统,故而可以从不同的角度对其进行分类。
OBJECTIVE: To evaluate research progress and clinical application of bisphosphonates for the treatment of multiple myeloma ( MM). 目的:评价双膦酸盐类药物在多发性骨髓瘤骨病治疗中的研究进展和临床应用情况。
Quality and Quality Control Study of Bisphosphonates 双膦酸类药物质量及其质量控制研究
Effects of bisphosphonates on proliferation of lung cancer cells in vitro 双膦酸盐对肺癌细胞增殖的影响
CONCLUSION: With the development of bisphosphonates, drug intensity has become more and more high, curative effect has lasted longer with less adverse reactions, so this kind of drug will have bright prospect for the treatment of MM. 结论:随着双膦酸盐类药物的开发进展,其药物强度越来越高,疗效更持久,不良反应更低,给多发性骨髓瘤骨病的治疗带来新的希望。
The Analysis of Bisphosphonates in Biological Samples 生物样品中双膦酸类药物的分析
Metastatic bone pain was partly relieved in 2 patients with osteolytic metastases treated with bisphosphonates. 2例溶骨型改变用博宁治疗均部分缓解;
Recent studies reveal that lower serum calcium levels are associated with greater calcium hydroxyapatite deposition in native aortic valves of male patients with severe calcific aortic stenosis and administration of bisphosphonates efficiently inhibit calcification. 新近研究证实,患有主动脉狭窄的男性患者,血清钙越低者主动脉瓣膜钙羟磷灰石沉积越显著,给予二膦酸盐可以有效的抑制钙化。
Bisphosphonates as Bone-targeted Agents to Treat Osteoporosis 双膦酸作为骨靶向载体治疗骨质疏松症的研究进展
Evaluation of Bisphosphonates for the Treatment of Multiple Myeloma 双膦酸盐类药物治疗多发性骨髓瘤骨病的评价
A Synthetic Method of the Bone Resorption Inhibitor Amino bisphosphonates and Their Sodium Salts An intermediate of bone resorption inhibitor risedronate sodium, 3 pyridine acetic acid hydrochloride, was synthesized from ethyl nicotinate via reduction, chlorination, cyanation and hydrolysis. 骨吸收抑制剂氨基二膦酸类化合物及其钠盐的合成以烟酸乙酯为原料,经还原、氯代、氰化、水解等反应合成了骨吸收抑制剂利塞膦酸钠中间体3-吡啶乙酸盐酸盐。
Part 3 Alendronate modulates angiotensin ⅱ-induced neonatal cardiac fibroblast proliferation differentiation and collagen production in vitroBackground: Nitrogen-containing bisphosphonates ( N-BPs), are extensively used in bone-related diseases and cancers. 第三部分阿伦磷酸钠对血管紧张素Ⅱ诱导心肌成纤维细胞的增殖分化和胶原形成的影响研究背景:含氮类双磷酸盐(N-BPs)广泛用于骨骼相关性疾病和肿瘤中。
Bisphosphonates with a imidazole ring have higher affinity for bone mineral, and zoledronate is just a good example which is extensively used clinically for the treatment of patients with tumour-induced, hypercalcaemia and osteolytic bone metastases. 含咪唑环的双膦酸盐具有很高的亲骨性,典型的例证是广泛用于治疗肿瘤引起的高钙血症、骨转移和骨质疏松症等方面疾病的唑来膦酸。
Nowadays, many medicines for osteoporosis have some disadvantages such as adverse side effects or a high cost, which including salmon calcitonin, bisphosphonates and human parathyroid hormone. 目前,用于治疗骨质疏松症的西药,如鲑鱼降钙素、双膦酸盐类和重组人甲状旁腺素等,具有明显的副作用且价格昂贵。
AT present, drug treatment, has become the main Methods to be used in the treatment of bone metastasis pain, the main use of Opioids, Bisphosphonates, Calcitonin. 目前常用于治疗骨转移瘤疼痛的方法有药物治疗,主要使用阿片类药物、双膦酸盐、降钙素等。