Charge transfer reaction of cinnarizine and alizarin in methanol with the presence of a little water 少量水存在下桂利嗪和茜素在甲醇中的荷移反应
Objective: To investigate the therapeutic effect of Cinnarizine in treatment of irritable bowel syndrome ( IBS). 前言:目的:观察桂利嗪在临床中治疗肠易激综合征(IBS)的疗效。
Objective: To develop a mouse model of radiation-induced brain injury ( RIBI), and then study the effects of the traditional medical blood-activator ( TMBA) and cinnarizine ( CA) in treating RIBI using this model. 目的:建立小鼠放射性脑损伤模型,并用该模型研究活血化瘀中药及脑血管扩张药物对放射性脑损伤的治疗效果,以便为临床上早期发现和防治放射性脑损伤提供线索。
The control group was treated with oral cinnarizine, vitamine C and compund salvia miltiorrhiza intravenously. 对照组口服脑益嗪片、维生素C片、静滴复方丹参注射液。
These change are believed to be the important mechanism of how cinnarizine prevents motion sickness. 这些变化可视为脑益嗪抗运动病作用的重要机理。
It was found that the solubility of cinnarizine decreased with the increased pH value in the buffer solution. 结果表明,桂利嗪片的溶出度随溶液pH值的升高而降低。
Effects of Cinnarizine on Experimental Thrombus Formation in Rats 脑益嗪对实验性血栓形成的影响
Rats and rabbits were stimulated with rotation, influences of cinnarizine were then observed on EEG power spectra of rats and cerebral blood flow of rabbits after this rotatory stimulation. 给予大鼠及家兔旋转刺激,观察脑益嗪对旋转刺激后大鼠脑电功率谱和家兔脑血流图的影响。
Open-label trial of cinnarizine in migraine prophylaxis 桂利嗪预防偏头痛的开放标记试验
Effects of cinnarizine on spontanous beating and electrical potential of cultured rat heart cells 桂利嗪对体外培养心肌细胞搏动和电位的影响
Effect of Cinnarizine on the Models of Dysmnesia Induced by Excitotoxicity in Rats 桂利嗪对兴奋毒诱导大鼠学习记忆障碍的影响
In the cinnarizine group, the rotation stimulation was performed 1 hour after cinnarizine injection. 在脑益嗪组,SD大鼠预先注射脑益嗪,1小时后如运动病组进行旋转刺激;
Image and Quantity Analysis of Prostaglandin in Rats 'Blood Plasma and Na+ K+ ATPase in Their Cerebellum During the Prevention of Motion Sickness by Cinnarizine 脑益嗪抗运动病时大鼠血浆PG和小脑Na~+K~+ATPase图像分析定量研究
Conclusion: The central mechanism of cinnarizine in preventing motion sickness is considered to be closely related to the quick expression of c fos gene in the brain tissues. 在脑益嗪组c-fos基因表达水平和Fos蛋白含量均低于运动病组。结论:脑益嗪抗运动病的中枢机理之一可能与c-fos基因快速表达有关。
Results: The apparent solubility of cinnarizine was significantly enhanced by increased HPCD concentration and decreased pH value and the apparent solubility constant was calculated. 结果:随着2-羟丙基β-环糊精浓度增加和pH的减小,桂利嗪的溶解度显著提高。计算了不同pH下包合物的表观稳定常数。
Clinical Research on Radiopotentiation of Cinnarizine and Cisplatin in Treating Esophagus 氟桂利嗪、顺铂对食管癌放射增敏作用的临床研究
These results suggested that the protective effect of cinnarizine on motion sickness should result from a dilatation of the brain blood vessels under pathological contraction caused by vestibular stimulation and do not do away with the reduction of the sensitivity of vestibular organs. 实验结果提示:当前庭受过度刺激时脑益嗪可能通过扩张病理收缩状态的脑血管来对抗运动病的发生,同时也不排除其降低前庭器官敏感性的作用。
The effect of cinnarizine, nicardipine on the collagen synthesis of human lung fibroblasts 桂利嗪、尼卡地平对人成纤维细胞胶原合成的影响
Effective vestibular stimulation might cause the tension of brain blood vessels. Cinnarizine could improve the brain blood flow during the vestibular stimulation and also reduce the frequency and velocity of slow phase of post rotatory nystagmus. 脑血流图功率谱的计算机分析表明,有效的前庭刺激可以引起脑血管的紧张,而脑益嗪能够改善前庭刺激下的脑血流状况,并且降低旋转后眼震颤的频率和慢相速度。
Conclusion: HPCD is an ideal solubilizer for cinnarizine. 结论:对于难溶性药物桂利嗪,2-羟丙基β-环糊精是较理想的增溶剂。
The rats that were subjected to rotational stimulation engaged in pica were used as the experimental models, The actions of cinnarizine in preventing motion sickness were studied. 以旋转后产生异嗜高岭土行为的大鼠作为运动病模型,观察脑益嗪的抗运动病作用。
Effects of cinnarizine on the REG power spectrum and nystagmus of rabbits during rotatory stimulation were studied. 研究了脑益嗪对受前庭刺激家兔的脑血流图功率谱和眼震颤的影响。
Aim: To explore the relationship between the CNS mechanism of anti motion sickness effect of cinnarizine and the c fos gene expression in the brain cells. 目的:探讨脑益嗪抗运动病作用的神经中枢机理与脑细胞c-fos基因表达的关系。