ADJ-GRADED 穷困潦倒的;无家可归的 If you describe someone as down-and-out, you mean that they have no job and nowhere to live, and they have no real hope of improving their situation.
...a short story about a down-and-out advertising copywriter... 关于一个穷困潦倒的广告文案的短篇故事
He looked unshaven, shabby, and down-and-out. 他看上去胡子拉碴、衣衫褴褛、穷困潦倒。
Down-and-out is also a noun.
...some poor down-and-out in need of a meal... 一些饥肠辘辘、无家可归的穷人
They are both down-and-outs, sleeping under the city's oldest bridge. 他俩都是无家可归的人,露宿在城市最古老的桥下。