The enantiomer that rotates the plane to the right is referred to as the dextrorotatory. 使平面向右旋转的对映体,称为右旋对映体。
Celiprolol enantiomer was resolved directly by using normal phase HPLC with urea derivative as chiral stationary phase ( CSP). 用脲衍生物型手性固定相直接拆分了药物对映体噻利洛尔。
It was found that resolution of enantiomer of neutral compound was enhanced by adding certain amount of methanol. 同时发现,一定含量的甲醇可以提高中性化合物对映体分离度。
Liquid Chromatographic Enantiomer Separation of Non-steroidal Anti-inflammatory Drugs on Crown Ether Type Chiral Stationary Phase 非甾体抗炎药对映体在冠醚手性固定相上的拆分
Enantiomer fraction ( EF) is used to investigate the atmospheric transport and exchange of chiral pesticides with soil and water. 利用手性农药的对映体分数可研究农药在土壤-大气,水体-大气间的迁移过程;
Identification of Two Strains Producing Single Enantiomer of 2-Piperazine carboxylic Acid 2株哌嗪-2-羧酸单一对映体产生菌的鉴定
Comparative enantiomer separation of β-blockers on polysaccharide derived chiral stationary phases using high performance liquid chromatography with acid or base additive in the mobile phases 多糖衍生物手性固定相上采用酸性或碱性添加剂的流动相拆分β受体阻滞剂对映体
Study on the Test for Related Substances of Primaquine Phosphate by TLC and Its Enantiomer 薄层色谱法检查磷酸伯氨喹的有关物质及对映异构体的研究
The concentrations of enantiomer in the receiver solution were assayed by HPLC using α-acidic glycoprotein chiral column. 应用α酸性糖蛋白手性柱(AGP)拆分、测定透皮接受液中酮洛芬对映体的含量。
Determination of Propranolol Enantiomer Glucuronides in Urine by HPLC 尿中普萘洛尔对映体葡醛酸苷的HPLC测定
Objective: To establish an HPLC method for the resolution of metoprolol enantiomer using chiral mobile phase additives. 目的:建立HPLC手性流动相添加剂法拆分美托洛尔对映体的方法。
Combined Application of Metal Catalysis and Bio-Catalysis in Enantiomer Resolution Process 金属催化和生物催化在对映体拆分中的联合应用
S: The enantiomer of chiral drug has strong stereoselectivity in vivo, which therefore makes the enantiomers have different pharmacokinetics and pharmacodynamics. 手性药物对映体在体内的手性环境中表现出强烈的立体选择性,对映体之间表现出不同的药动学和药效学性质。
Enantiomer-Selective Chemical Sensors and Chiral Ionophores 对映体选择性化学传感器与手性识别载体研究
Enantiomer Separation of 2 Chloro 1 Phenylethanol and 2 Bromo 1 Phenylethanol by Chiral High Performance Liquid Chromatography 2-F氯-1-苯基乙醇和2-溴-1-苯基乙醇对映体的高效液相色谱分离
The configuration inversion can offer the desired enantiomer in high efficiency, but with certain limitation in application. 构型反转能够直接得到所需要的对映体,效率高,但其应用局限性较大;
Comparative study of chiral separation of ofloxacin enantiomer by capillary electrophoresis using neutral cyclodextrins 中性环糊精毛细管电泳法手性拆分氧氟沙星对映体的对比
Conclusion: The established method is suitable for the determination of chiral impurity and enantiomer excess in the d-zopiclone. 结论:本法可用于测定合成右旋佐匹克隆过程中对映体过量(ee)和右旋佐匹克隆中手性杂质的含量[1]。
The development of enantiomer separation concerning chiral selectors, theory, methods and applications are introduced. 以各种手性选择剂的发展为线索介绍了毛细管电泳手性分离理论、方法及应用。
Enantiomer separation is one of the most important research fields of chiral technology. 手性拆分是手性技术的重要研究方向。
RESULTS The plasma concentrations of two enantiomer were different. 结果最大血药浓度时两个对映体在人体血浆中的浓度有不同程度的差异。
AIM: To compare the separation ability of different neutral cyclodextrins ( CD) and their derivatives on ofloxacin enantiomer by capillary electrophoresis ( CE) and to explore the possible mechanisms of chiral separation. 目的比较在毛细管电泳中不同中性环糊精(CD)及其衍生物对氧氟沙星对映体的手性拆分能力,并提出可能的手性识别机制。
Study on the enantiomer separation of pazufloxacin mesylate by RP-HPLC using chiral mobile phase additives RP-HPLC手性流动相添加剂法拆分甲磺酸帕珠沙星对映体的研究
OBJECTIVE To develop a chiral HPLC method for the determination of enantiomer of valsartan. 目的建立测定缬沙坦对映体的高效液相色谱方法。
Chiral stationary phases ( CSPs) are the key to enantiomer separation. 手性固定相是对映体分离的关键因素。
Chiral drugs has been a research hotspot in drug development field because its different enantiomer may possess different pharmacodynamic and pharmacokinetics effects in absorption, translocation, effect, metabolism and excretion process because there are chiral locus in most endogenous substance. 手性药物因其不同对映异构体在体内的吸收转运、分布、起效、代谢和排泄的过程中均可能对内源性物质有不同甚至相反的作用而成为药物开发领域的一个研究热点。
The different reactive rates of the two enantiomer may lead to the differential pharmacodynamics and toxicities. 两个对映体若以不同的反应速率进行葡萄糖醛酸结合反应,会导致其表现出有差别的药效和毒性行为。
Enantiomer excess ( ee) values of the products were determined by chiral HPLC. 用手性高效液相色谱法测定产物的对映体过量值(ee值)。
For example, unwanted side effects or even toxic effects can occur with the second enantiomer in several cases. 例如,在许多情况下,第二种对映体往往会产生不必要的副作用甚至毒性。
β-hydroxy ester with optical activity, whose enantiomer was often used as chiral block in the organic synthesis and intermediate for drug production, was one of the important compounds. 具有光学活性的β-羟基酯类化合物是一类重要的化合物,其对映体通常被用来作为有机合成的手性砌块,或作为合成一些天然化合物和药物的中间体。