The results indicated that hydroxylproline content in skin and extracted collagen increased with age and stabilized at maturity. Before maturity, the collagen dissolution rate of the female rats was higher than that of male rats. 结果表明BN大鼠随着年龄增长到成熟期,皮肤组织和提取的胶原蛋白中羟脯氨酸含量都逐渐升高,然后趋于稳定。