Technical requirements from ICH for Preclinical Cardiac Safety Evaluation of Pharmaceuticals ICH对药物临床前心脏安全性评价的技术要求
Objective To explore the clinical features of early epileptic seizures ( EES) after intracerebral hemorrhage ( ICH). 目的探讨脑出血后早发性癫癎发作的临床特点。
Objective: To study the influence of Nao Xue Kang ( NXK) tablet on brain tissue ultrastructure in acute intracerebral hemorrhage ( ICH) rat. 目的:探讨脑血康对急性脑出血大鼠脑组织超微结构的影响。
Much of the content of ICH Q10 applicable to manufacturing sites is currently specified by regional GMP requirements. 适用于质量地址ICHQ10的许多内容当前已经被地区GMP要求具体要求。
Notably, the background incidence of ICH is higher in Black, Hispanic and Asian patients than in White patients. 值得注意的是,颅内出血在黑人、西班牙人和亚洲人中的发生率比白种人高。
ICH Q10 is not intended to create any new expectations beyond current regulatory requirements. ICHQ10并不是旨在创建超越现行法规的新期望。
In this article, combined with the regulation in ICH guidance and the clauses for controlling heavy metal in USP, the methods to control heavy metal in inorganic impurity was discussed and analyzed. 结合ICH指南的规定和USP关于重金属控制的专论内容,对如何控制无机杂质中重金属类杂质进行了探讨和分析。
Degradant results may be higher or lower than the ICH reporting threshold from time point to time point. 降解产物的结果在不同的时间点可能会高于或低于ICH的报告限。
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To explore the initial factor of apoptosis may find a new therapeutic strategy for ICH. 探讨细胞凋亡的始动因素,可为脑出血寻找新的治疗策略。
Where appropriate, the stability storage conditions should be consistent with the ICH guidances on stability. 根据情况,稳定性储存条件应当与ICH的稳定性指南一致。
Advanced maternal age, African American race, hypertensive diseases, coagulopathy, and tobacco abuse were all independent risk factors for pregnancy-related ICH. 孕妇高龄、非洲美洲血统、高血压疾病、凝血障碍和烟草滥用均是妊娠相关性ICH的独立危险因素。
Methods should be validated to include consideration of characteristics included within the ICH guidances on validation of analytical methods. 方法验证应当包括ICH分析方法验证指南中的特征的考虑。
The risk of ICH associated with pregnancy is greatest in the postpartum period. 妊娠时在产后期发生ICH的风险最高。
ICH Score for Predicting of Outcome of Spontaneous Intracerebral Hemorrhage 自发性脑出血评分量表对自发性脑出血预后的评价作用
The mechanism of nerve cell death following intracerebral hemorrhage ( ICH) is complex. 脑出血后神经细胞死亡的机制复杂。
Recent studies have suggested that apoptosis involved in nerve cell death following ICH. 最近的研究表明,凋亡机制参与了脑出血后神经细胞的死亡。
As stated in ICH Q8, movement within the design space is not considered a change ( from a regulatory filing perspective). 如ICHQ8中说明的,设计空间范围内的移动不能被视为变更(从注册文件的角度)。
In this decade, an attempt has been made to harmonize the requirements in the form of an ICH GCP document which has been adapted as regulation by many countries. 在这的十几年,ICHGCP文件作为一个尝试,用来协调这种要求,已经被许多国家作为法规采用。
Conclusion: Intracerebral hemorrhage ( ICH) accounts for a substantial portion of pregnancy-related mortality. 结论&ICH在妊娠相关性死亡中占着重要的部分。
Methods To study retrospectively the clinical materials of1288 patients who have been diagnosed to have an ICH. 方法对1288例确诊为脑出血患者的临床资料进行回顾性研究。
Biotechnology considerations are covered in ICH Guideline Q6B. 生化技术的考虑在ICH指南Q6B中。
Objective: To explore the mechanism of Naoyian granule ( NYA) in treatment of intracerebral hemorrhage ( ICH). 目的:探讨脑溢安颗粒剂(NYA)治疗脑出血的作用机制。
Changes of COX-2 and brain edema in hyperglycemia rats after experimental ICH 高血糖大鼠脑出血后脑水肿及COX-2的变化
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ICH Guideline on Genotoxicity: Latest Progress in Revision ICH遗传毒性研究指导原则修订的最新进展
The ICH shall not be used in the form of distortion, derogation, etc. 禁止以歪曲、贬损等方式使用非物质文化遗产。
Objective: To initially study the influence factors to cerebral shock stage after hypertension cerebral hemorrhage ( ICH). 目的:初步研究高血压脑出血(ICH)后脑休克期的影响因素。
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Results The incidence of EES after ICH is8.31%; 结果脑出血后早发性癫癎发作的发生率为8.31%;