methylation
英
美
n. 甲基化；甲基化作用
复数：methylations
BNC.31542
双语例句
- They found 88 sites on the mens DNA where the amount of methylation correlated with their ages.
他们发现男性DNA上有88个地方的甲基数量与他们的年龄有关。 - This phenomenon is mostly seen in imprinted genes and X-chromosome inactivation where DNA methylation of promoter regions leads to repression of gene expression.
这种现象主要在印迹基因和X染色体失活区域看到，这些区域中的启动子区的DNA甲基化导致了基因表达的抑制。 - Alterations in DNA methylation, an important regulator of gene transcription, lead to cancer.
对调节基因转录起重要作用的DNA甲基化的异常将导致癌症的发生。 - Researchers looked for-and found-a chemical change called DNA methylation in healthy tissue adjacent to breast tumors.
研究者寻找并发现了靠近肿瘤组织的健康组织中有“DNA甲基化”这种化学改变。 - This is the first report on the methylation patterns of in vitro-derived mouse tetraploid embryos.
这是对小鼠四倍体早期胚胎基因组甲基化模式的首次报道。 - The work is one of several clues that DNA methylation affects the formation and maintenance of memories.
这项工作是DNA甲基化影响记忆形成和延续的线索之一。 - Cytosine methylation silences transposable elements in plants, vertebrates, and fungi but also regulates gene expression.
胞嘧啶的甲基化能够沉默植物、脊椎动物和真菌的转座元件，同时也能调控基因的表达。 - DNA methylation is a frequent change in epigenetics of leukemia.
DNA甲基化是白血病表观遗传学改变中较常见的改变。 - CONCLUSION: The generation of genome sequence and DNA methylation data is expected to accelerate greatly.
结论：基因组序列和DNA甲基化数据的产生有望大大加速。 - Endometrial neoplasms; Spleen tyrosine kinase; Gene, tumor suppressor; DNA methylation.
子宫内膜肿瘤；脾酪氨酸激酶；基因，肿瘤抑制；DNA甲基化。 - A polysaccharide of unknown structure was isolated, subjected to exhaustive methylation, and hydrolyzed.
一未知结构的多糖，经完全甲基化和水解。 - Three candidate methylation differences were validated by targeted pyrosequencing assays.
三个候选甲基化差异通过靶向焦磷酸测序实验进行了验证。 - CHH methylation of small transposable elements is increased in embryos, suggesting that endosperm demethylation enhances transposon silencing.
胚中小的转座元件CHH甲基化作用发生了增强，表明了胚乳的去甲基化增强了转座元件的沉默。 - The information in this study is important for its extensive utility in gene feature analysis and epigenomics including gene prediction and methylation chip design in different genomes.
本研究中的信息对于其在基因特征分析和表观基因组学中的广泛的应用是重要的，包括在不同基因组中的基因预测和甲基化芯片设计。 - The changes of epigenetics such as DNA methylation and histone modification can regulate the expression of genes and play an important role in the development of tumors.
表遗传学改变，如DNA甲基化和组蛋白修饰改变可以调节基因的表达，在肿瘤的发生和发展中可能起关键作用。 - Study on Gene Promoter Methylation and Prostate Cancer Development
基因启动子甲基化与前列腺癌的相关性研究 - In some cases, the substrate of methylation can be inferred from hidden Markov model sequence similarity networks.
在某些情况下，甲基化的酶作用物能够从隐马尔科夫模型序列相似性网络中被推断。 - It stores information about the origin of the investigated sample and the experimental procedure, and contains the DNA methylation data.
它存储了有关研究样品来源信息和实验步骤信息，并包含了DNA甲基化数据。 - DNA methylation and its aberrance play an important role in the human development and tumorigenesis.
DNA的甲基化及甲基化异常在人体发育和肿瘤的发生中起着至关重要的作用。 - Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.
活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。 - We present here a database for DNA methylation data that attempts to unify these results in a common resource.
这里我们提出了一个DNA甲基化数据库，它试图在一个公共资源中统一这些结果。 - Here, we outline the currently used methylation detection reagents and their application to microarray and sequencing platforms.
这里，我们概述了当前用于甲基化检测的试剂，及它们在微阵列和测序平台上的应用。 - We explored this concept in the placenta to define whether DNA methylation is cell-type specific.
我们在胎盘中探索了这个概念以定义DNA甲基化是否是细胞类型特异的。 - Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.
靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。 - Objective To investigate methylation of BLU gene in hepatocellular carcinoma.
目的了解肝细胞癌中BLU基因的甲基化状态及临床意义。 - Epigenetic processes, such as DNA methylation, are known to regulate tissue specific gene expression.
已知表观遗传过程，例如DNA甲基化调控组织特异基因表达。 - Many studies have explored the mosaic patterns of DNA methylation and histone modification in cancer cells on a gene-by-gene basis;
很多研究已经在逐基因地基础上探寻了癌症细胞中DNA甲基化和组蛋白质修饰的镶嵌模式； - This results in a considerable reduction in the time required for completion of a detailed genomic methylation project.
这种结果相当大的减少了完成一个详细的基因组甲基化项目所需要的时间。 - We investigated the association between gene methylation and recurrence of the tumor.
我们研究基因甲基化和肿瘤复发的相关性。 - DNA methylation? repeat sequence? trans-inactivation and co-suppression are the most important reasons what induce transgene silencing.
甲基化、重复序列、反式失活和共抑制是基因沉默的主要诱因。