We suggest that the activity of the MLL complex might be regulated through this interplay. 研究者认为,MLL复合物的活性可能受到这些相互作用的调控。
In this case, the duplication within the MLL gene contributes to an aggressive form of AML. 这种情况下,MLL基因中的复制导致AML的的侵略性。
When the MLL switch is broken, white blood cells do not mature properly, resulting in a dangerous proliferation of abnormal cells. 当MLL开关被破坏后,白细胞就无法正常成熟,并导致一种危险地非正常细胞的增殖。
The one of most interesting issues is how leukemia cells with MLL rearrangement acquire a unique feature of TRAIL-resistance. 非常有意思的问题之一是有MLL重排的白血病细胞怎样获得抵抗TRAIL的唯一特征。
The genetic change, known as a partial tandem duplication, is located in a gene called MLL ( for mixed-lineage leukemia). 该基因改变,即所谓的部分串联复制,位于MLL(混合血系白血病)基因上。
In normal cells, MLL combines with four proteins that comprise the W-RAD group to create a molecular switch that controls DNA packaging events required to form white blood cells. 在正常细胞中,MLL与其他四种蛋白联合组成了W-RAD复合体,从而形成了在白细胞形成中所需的一种控制DNA组合的分子开关。
Gene expression profile analysis of the ALL cells demonstrated significant overlap with human MLL-rearranged ALL. ALL细胞基因表达状况分析表明其与人MLL重排的ALL具有相当的重叠。
Conclusions Genotypes defined by the mutational status of NPM1, FLT3, CEBPA, and MLL are associated with the outcome of treatment for patients with cytogenetically normal AML. 结论:由NPM1,FLT3,CEBPA,和MLL基因的突变状态所界定的基因型与细胞遗传学正常的急性髓细胞白血病患者的临床治疗结局之间存在相关性。
Characteristics of Fusion Gene and Immunophenotype in MLL Gene Rearrangement Positive Childhood Acute Lymphoblastic Leukemia MLL基因重排阳性的儿童急性淋巴细胞白血病的融合基因及免疫表型特点
Studies on Detection of Rearrangements of MLL Gene in Acute Monocytic Leukemia 急性单核细胞白血病的MLL基因重排检测的研究
Thus, further exploration is necessary to overcome the TRAIL-resistance of ALL with MLL rearrangement. 因此需要进一步研究才能克服说明所有带有MLL重排的细胞都抵抗TRAIL。
Objective To characterize the morphological feature of mixed lineage leukemia ( MLL) gene related leukemia, and determine the correlation of MLL rearrangements with FAB subtypes. 目的通过观察混合系白血病(MixedLineageLeukemia,MLL)基因相关白血病患者骨髓细胞形态学特征,了解MLL基因重排特征与FAB形态学分型的关系。
Objective To study the clinical and laboratory features of childhood acute leukemia with MLL gene rearrangements. 目的对儿童急性白血病(acuteleukemia,AL)MLL基因重排进行临床和实验研究。
Purpose To study the clinical and pathological features of the mucocele-like lesions of the breast. 目的:研究乳腺黏液囊肿样病变(MLL)的临床病理特征。
Results On plain scan, hypodense lesion was a common presentation of MLL. 结果MLL平扫密度较低。
Conventional Cytogenetics and Fluorescence in situ Hybridization as Methods for Detecting MLL Gene Rearrangements in Leukemia 常规细胞遗传学分析和荧光原位杂交方法检测白血病11q23/MLL基因重排
It is concluded that for accurate diagnosis both CC and FISH are needed for detecting 11q23/ MLL gene rearrangements, and evaluation is needed in combination of these two results. When necessary, it needs to do sequential R-banding and FISH or molecular analysis. 结论:为了给出准确的诊断,在检测11q23/MLL重排时需要进行常规细胞遗传学和间期FISH测定并结合两者结果来评定,必要时需做R显带后FISH或进一步的分子生物学分析。
Conclusion Multiplex RT-PCR combined with FISH provided a more accurate and sensitive method for detection of MLL gene rearrangements. 结论多重RT-PCR和FISH联合是检测MLL重排最精确和灵敏的方法,MLL基因重排中包括易位、缺失和重复。
Acute leukaemia patients with translocation rearrangements of 11q23/ MLL gene have hazardous clinical symptoms and worse prognosis. 有11q23/MLL基因易位重排的AL患者临床症状凶险,预后差。
Combination of interphase-and metaphase-fluorescence in situ hybridization to identify 11q23/ MLL abnormalities in acute leukemia patients 联合间期和中期荧光原位杂交确定成人急性白血病患者11q23/MLL异常
Easy to use. MLL was likely to recur. MLL易复发。
R bands by heating using Giemsa ( RHG) banding technique was used for karyotype analysis. mixed lineage leukemia ( MLL) rearrangement was detected by interphase fluorescence in situ hybridization ( FISH) using dual color MLL probe in 10 cases. 采用双色混合谱系白血病(MLL)基因探针和间期荧光原位杂交(FISH)技术,对其中10例AL进行MLL重排检测;
The detection of MLL gene rearrangement is of great importance in predicting prognosis and guiding therapy in AL. MLL基因重排的检测对急性白血病预后判断和治疗方案的选择具有重要意义。
Objective: To study the incidence, frequent types of fusion genes and clinical significance of translocation rearrangements of 11q23/ MLL gene in acute leukaemias. 目的研究11q23/MLL基因易位重排在急性白血病(AL)中的发生率、产生融合基因的常见类型及其临床意义。
ML with bone marrow involvement ( BMI) was found in 32 cases ( 31.68%). Among them, 8 with malignant lymphoma leukemia ( MLL). 恶性淋巴瘤的骨髓侵犯(BMI)32例(31.68%),其中恶性淋巴瘤性白血病(MLL)8例。
According to space-time characteristics of dynamic texture, we establish neighborhood system and energy function of MLL model in marking field, and describe observations with Gaussian Markov Random Field. 根据动态纹理的空时特性,确立标记场MLL模型中的邻域系统和能量函数,并采用高斯马尔可夫随机场描述观察场。