In fact, researchers hypothesize that modafinil, the real-world drug most like the fictional drug from the movie Limitless works in part because it increases orexin. 事实上,研究人员假设莫达非尼能让人精力充沛,这种确实存在的药物类似电影《永无止境》里的虚拟药物,因为它也能增加体内的阿立新。
The drug is called "modafinil" and, unlike other stimulants, it has no side effects. 这种药叫做“莫达非尼”(modafinil),而与其它兴奋剂不同的是,它没有副作用。
Modafinil is a novel central stimulant for the treatment of narcolepsy and idiopathic hypersomnia. 莫达非尼是一种新型精神兴奋剂,治疗发作性睡眠症及自发性睡眠过度。
Recent progresses in the study of modafinil were reviewed, especially on the mechanism, in this paper. 综述近几年来莫达非尼的研究进展,着重阐述其可能的作用机制。
Narcoleptics, people who often fall asleep quite suddenly, currently use the drug to ease their condition, and there is potential for modafinil to keep the rest of us up all night, too. 常常忽然睡着的嗜睡症患者,通常用此药来减轻他们的症状,而“莫达非尼”也有可能让我们其余的人都能整晚不睡呢。
Effect of modafinil on cognition and synaptic plasticity after REM sleep deprivation in rats; 目的探讨大鼠脑梗死后树突可塑性的物质基础和机制及针刺的影响。
There is already anecdotal evidence of troops using the narcolepsy drug modafinil, and ritalin, which is prescribed for attention deficit disorder, to boost their performance. 目前已有证据部队使用嗜睡症的药物莫达非尼和利他林,这本是用来医治注意力缺失症的,以提高他们的表现。
Objective To investigate the effects of modafinil, a new wake-promoting agent, on vestibular function during 24 h sleep deprivation ( SD). 目的观察24h睡眠剥夺(SD)条件下服用莫达非尼对正常人前庭功能的影响。
Objective: To study the nuclear magnetic resonance ( NMR) spectrum of modafinil acid and modafinil sulfone. 目的:对莫达芬尼酸和莫达芬尼砜进行核磁共振波谱(NMR)研究。
Method: The γ-scintigraphic tracer was used to investigate the gastrointestinal transport and disintegrating release of modafinil pulsatile controlled-release tablets in vivo. 方法:采用γ-闪烁显像示踪技术观察脉冲片在胃肠道转运和崩解释药情况。
Objective To investigate the effect of diazepam and modafinil on acute hepatic failure in mice. 目的:研究地西泮、莫达非尼对小鼠试验性急性肝衰竭的影响。
Effects of modafinil on flight performance and mood states of military student pilots 莫达非尼对军事飞行学员飞行工作能力和情感状态的影响
RESULTS: The waking effect of 8-10 h induced by modafinil before and after sleep deprivation was similar and was not followed by an increase in sleep rebound. 结果:莫达非尼在取消睡眠前或取消睡眠后引起的觉醒作用相同(8-9h),并且不增加后续睡眠的反弹。
Effect of diazepam and modafinil on acute hepatic failure in mice 地西泮和莫达非尼对小鼠试验性急性肝衰竭的影响
Compared with placebo group, CFF in modafinil group was significantly increased and subjective sleepiness and fatigue level were remarkably decreased. 与安慰剂组相比,莫达非尼组的CFF明显增加、主观嗜睡和疲劳感显著降低。
Conclusions Modafinil given at routine, single dose ( 200mg) had no significant adverse effect on flight performance, and could significantly enhance the ability of stress reaction and lower the subjective fatigue level. 结论服用常规单剂量莫达非尼(200mg)对飞行工作能力无明显不良影响,并有明显提高机体应激反应能力、降低主观疲劳感的作用。
Numbers of errors during 48 h SD and at 1:00~ 7:00 of the third day in modafinil group was 19% and 40% lower than those in placebo group respectively. 莫达非尼组48hSD总的操作错误数较安慰剂组降低了19%,第3天1:00~7:00的错误数较安慰剂组降低了40%。
Modafinil ( 200 mg) or placebo was given at 10 ∶ 30 ( 2 h before flying). 在飞行前2h(10∶30)分别服用莫达非尼或安慰剂200mg。
A Study on Nuclear Magnetic Resonance Spectrum of Modafinil Acid and Modafinil Sulfone 莫达芬尼酸及莫达芬尼砜的核磁共振波谱研究
Conclusion Twenty four SD can influence vestibular function in certain degree, but optokinetic nystagmus can be improved by modafinil. 结论24hSD会影响正常人体的前庭功能,服用莫达非尼对其中的视动性眼震具有一定的改善作用。
Randomized controlled trial of modafinil for the treatment of fatigue in postpolio patients 莫达非尼治疗脊髓灰质炎后患者疲劳的随机对照试验
Effects of modafinil on human basic+ G_z tolerance and Coriolis acceleration tolerance 莫达非尼对人体基础+Gz耐力和科里奥利加速度耐力的影响
Modafinil for excessive sleepiness associated with shift-work sleep disorder 莫达非尼对轮班工作睡眠障碍相关性过度嗜睡的作用
Effect of modafinil on locomotor activity in mice 莫达非尼对小鼠自主活动的影响
Cognitive effects of central stimulant modafinil and their probable mechanisms 中枢兴奋剂莫达非尼对认知功能的影响及可能机制
Conclusion Treatment with diazepam may suppress the D-GalN/ LPS-induced acute hepatic failure and modafinil may facilitate the acute hepatic failure. 结论:地西泮可减轻DGalN/LPS所致的急性肝衰竭,提高小鼠的存活率,莫达非尼可加重小鼠的肝损伤。
Effects of modafinil on mathematical ability and perception during stress of sleep deprivation 莫达非尼对睡眠剥夺应激条件下计算能力和知觉加工的影响
CONCLUSION: These results suggest the efficiency of modafinil against somnolence and hypersomnia without increasing subsequent sleep. 结论:上述结果提示莫达非尼有效地拮抗嗜睡状态和过度睡眠症状而不引起后续睡眠时间的增加。