nelfinavir

1. Cancer-causing mutations can also activate the proteasome, so drugs that block protein breakdown, such as nelfinavir, could theoretically halt both diseases.
   变异的癌症细胞也可以激活蛋白酶体，像那非那韦之类阻断蛋白分解的药物，理论上可以治疗癌症。
2. The most effective of the three, nelfinavir, which impedes the activity of protein-degrading enzymes in the cell, also blocked tumour growth in mice injected with cancer cells.
   三种药物中，疗效最好的那非那韦，不仅可以阻碍细胞中的蛋白降解酶的活动，而且可以阻碍被注入癌细胞的小鼠肿瘤的生长。
3. The drugmaker added that the EMS impurities were caused by the manufacturing process of the drug, which is known generically as nelfinavir mesylate.
   药品制造商补充说，EMS杂质在药物生产过程中产生，通常认为是甲磺酸奈非那韦。
4. Results: Nelfinavir decreased insulin-stimulated phosphorylation of IRS-2 and Akt-Thr~ ( 308) in a dose-dependent manner;
   结果：nelfinavir降低胰岛素刺激的胰岛素受体底物IRS-2和Akt-Thr308磷酸化，并呈剂量依赖关系。
5. HIV-1 protease inhibitor nelfinavir decreases insulin secretion from rat insulinoma INS-1 cells
   HIV-1蛋白酶抑制剂Nelfinavir降低大鼠胰岛素瘤INS-1细胞胰岛素释放

noun

1. a protease inhibitor (trade name Viracept) used in treating HIV usually in combination with other drugs

   Synonym:    Viracept