Results: Strong expression of hNa v1.8 channel protein was found in the demyelinated fibers of the affected nerves in patients with TN, weak expression in the neuraxon of rat spinal nerve, and none in the normal inferior alveolar nerve and the great auricular nerve. 结果:hNav1.8通道蛋白在TN患者痛支神经的有髓纤维脱髓鞘处有大量表达,鼠脊神经轴突内有少量表达,而正常下牙槽神经及耳大神经中无表达。
Disappearance of the evoked potential was the major change of PTN-SEP, suggesting the damage of neuraxon due to TCS. 异常形式主要为诱发电位波形消失,提示TCS主要导致神经元轴索损害。
S100 β is one kind of the calcium binding proteins. As growth factor of neuraxon, it is excreted by neuroglial cell, and distributing in nerve tissue extensively. Although S100 β has very important values neurophysiological, it also has neurotoxicity with excreting overmuch. S100β是一类钙离子结合蛋白,是轴突的生长因子,由神经系统胶质细胞分泌,广泛分布于神经组织中,在正常情况下发挥重要的生理作用,但分泌过高具有神经毒性。