SS located in the cytoplasm of neurepithelium and mesenchyme and had a positive action on apoptosis; SS位于神经上皮和周围间充质细胞的胞质内,其含量与神经管形成过程中的细胞凋亡呈明显正相关关系。
Conclusion: Hyperthermia can promote the expression of SS and suppress the LN biosynthesis, which results in excessive apoptosis in the neurepithelium and mesenchyme. 结论:高温可促进胚胎SS的表达、短暂抑制LN的合成,从而诱导神经上皮和周围间充质细胞凋亡的发生,引起神经管畸形。
Results: ( 1) LN mainly located in the basement membrane of neurepithelium and regularly changed along with the development of neural tube by a negative role in apoptosis; 结果:LN主要位于神经上皮的基底膜,与神经管形成过程中的细胞凋亡呈负相关关系;