The effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation in young and aged rats 黑质内注射脂多糖对不同年龄大鼠DA能神经元和小胶质细胞活性的影响
Protective effect of edaravone against degeneration of rat substantia nigral dopaminergic neurons induced by lipopolysaccharide 依达拉奉对脂多糖诱导的大鼠多巴胺能神经元变性保护作用的研究
Objective: To observe the effects of Glutathione Combined with Kang-zhen Zhijing Capsule on the abnormal behavior, nigral antioxidation system and cell morphology of PD model rat and study its mechanism. 目的:观察还原型谷胱甘肽(GSH)合中药抗震止痉胶囊对帕金森病(PD)大鼠模型的异常形为、黑质抗氧化系统及细胞形态学的影响,并探讨其作用机制。
Prevention of neurotoxin damage of 6-OHDA to dopaminergic nigral neuron by subthalamic nucleus lesions 损毁丘脑底核阻止6-OHDA对大鼠多巴胺能神经元的损伤作用
Some of nigral cells contained acidophilic Lewy body with intense immune response to α-synuclein; 部分细胞胞质内出现αsynuclein免疫反应呈强阳性的Lewy小体;
Paraquat Could Increase Caspase-3 mRNA Expression and Its Enzymatic Activity in the Substantia Nigral Cells in Mice 百草枯增加小鼠黑质细胞caspase-3mRNA的表达及其酶活性
Nigral degeneration and Lewy body were viewed by HE staining; HE染色观察黑质变性和Lewy小体形态;
Objective: To explore the degeneration effects of lipopolysaccharide ( LPS) on substantial nigral dopaminergic ( DA) neurons and the pathogenesis of Parkinson diseases. 目的:观察脂多糖(Lipopolysaccharide,LPS)对黑质多巴胺(DA)能神经元的毒性作用,探讨帕金森病(PD)发病机制。
The experimental study of dopaminergic nigral degeneration on Parkinson's disease with high-frequence stimulation to the subthalamic 高频刺激底丘脑核阻止帕金森病黑质多巴胺能神经元变性的实验研究
Transplantation of Microencapsulated Pituitary-Hypothalamic-Nigral Cells 微囊胎垂体下丘脑黑质细胞移植研究
Aim: To explore the influence of paraquat on cerebral mitochondrial respiratory chain activity and the possible mechanism of paraquat to damage nigral neurons. 目的:探讨百草枯对黑质细胞线粒体呼吸链的影响和导致黑质细胞损害的可能机制。
Nigral Cells Transplanted into the Striatum of PD-RatS: Effect of NGF on Grafted Cells 黑质细胞移植于PD鼠纹状体及神经生长因子对移植细胞的影响
The induction of cultured rat embryonic subventricular zone neurons into substantia nigral neurons embryonic stem cells 胚胎大鼠脑室下区神经细胞体外培养和向黑质细胞定向诱导的实验研究
Conclusions Substantial nigral pathology of PD rats makes the foundation of the rotational behaviour. 结论PD大鼠旋转行为变化是有其病理学基础的。
CONCLUSION: TNF α pretreatment through injection into cerebellomedullary cistern of the MPTP treated mice may aggravate the damage of nigral dopaminergic neuron; the reason may be related to apoptosis induced by caspase 3. 结论:脑池内以TNF-α预处理MPTP小鼠,使黑质多巴胺神经元损伤加重,其途径可能与caspase-3引起的细胞凋亡相关。
Conclusion: 1. The loss of nigral dopaminergic neurons may occur via active apoptotic mechanism in MPTP-Parkinsonian mice. 结论:1.模型中多巴胺能神经元的丢失可能是通过细胞凋亡机制实现的;
Conclusion: 1.The grafted nigral cells can reconstruct the nervous function though integrating into host brain. 结论:1移植的黑质细胞能通过结构整合重塑神经功能。
Conclusions The study showed that apoptosis was a main death mode of nigral neuronal cells in 6 OHDA induced PD model rats, which may play a key role in the development of Parkinson's disease. 结论6-OHDA诱导PD模型鼠中脑黑质神经元存在以细胞凋亡为主的死亡方式,细胞凋亡在PD发病中可能起关键作用。
The roles of proteasome on nigral degeneration and Lewy body formation 蛋白酶体在脑黑质变性和Lewy小体形成中的作用
Flunarizine Affect Immunoreactivity of Nigral Microglial and Dopaminergic Neurons and Relationship of Them 氟桂利嗪对黑质小胶质细胞及多巴胺能神经元免疫活性的影响及其相互之间的关系
The objective of this research is to seek a new method to culture and induce the rat embryonic subventricular zone ( SVZ) neurons into the substantia nigral neurons. 本研究目的在于探寻体外培养和定向诱导胚胎大鼠脑室下区(SVZ)神经细胞向黑质细胞分化的新方法。
Conclusion: NSC could decrease the 6 hydroxydopamine induced lesions of the nigral dopaminergic neurons. 结论:神经干细胞移植能减轻6羟基多巴胺对黑质纹状体多巴胺能神经元的损伤。
Conclusions GSH could decrease the nigral oxidative stress, and exert some protective effect on mitocondrial respiration-chain. 结论(1)GSH能减轻黑质区氧化应激损伤,并对线粒体呼吸链具有一定保护作用;
Conclusions Apoptosis is the main way of nigral dopaminergic neurons 'death in acute course of PD models, and is the main cause leading to the decrease of tyroxine hydroxylase ( TH) in striatum. 结论进一步证明了黑质细胞凋亡是早期帕金森病模型大鼠黑质细胞死亡的主要方式之一,是纹状体区酪氨酸羟化酶(TH)减少的主要原因。
Iron induces the degeneration of nigral dopaminergic neurons in rats The effect of electroacupuncture on dopaminergic neurons 铁剂诱发黑质多巴胺能神经元变性电针治疗对帕金森病大鼠多巴胺能神经元的影响
Expressions of α synuclein and tyrosine hydroxylase in nigral cells were investigated by immunohistochemistry. 应用免疫组化观察黑质细胞αsynuclein和酪氨酸羟化酶(TH)的表达;
Objective To set up the Parkinson's disease ( PD) rat model with pathologic characteristic of Lewy body in nigral cells. 目的建立符合帕金森病(PD)病理特征&黑质细胞有Lewy体的PD大鼠模型。
The research expressed the protect function of bcl2 protein to nigral DA by anti-oxygenation. 研究表明,bcl2蛋白对黑质DA能神经元的保护作用可以通过抗氧化作用来实现。
The losing of nigral DA in midbrain is the most pathologic characteristic of PD. 中脑黑质DA能神经元的丢失是PD的主要病理特点。