The animals were then killed to observe the nigrities of colonic mucosa. 处死动物,观察结肠黑变情况;
[ Conclusion] Rhubarb can induce melanosis coli in guinea pig. The degree of nigrities correlated with dose and time of using rhubarb. [结论]用大黄可致豚鼠实验性结肠黑变病,黑变程度与大黄剂量及时间相关。