Conclusion Caffeic acid and ferulic acid are a new kind non-peptide ET antagonists. 放射性受体-配体结合实验表明,咖啡酸和阿魏酸可竞争性地抑制ET1与其受体结合。结论咖啡酸和阿魏酸为新的非肽类ET1拮抗剂。
Antihypertensive non-peptide angiotensin II receptor antagonists have been paid much attention since it was found in 1980 's. 抗高血压新药非肽类血管紧张素II受体拮抗剂自二十世纪八十年代发现以来就受到了广泛的关注。
These simulated polymers were the alternating copolymers formed by oligopeptide segment and non-peptide segment instead of the pure protein. 所合成的模拟聚合物并不是蛋白质,而是短链多肽与非多肽片段的交替共聚物。
TPO mimetic peptide acquired by affinity screening and non-peptide mimics acquired by function screening can stimulate the prolification, mature of megakaryocyte and increase the platelet numbers. These two mimics are equipotent a to TPO in vitro in bioactivity. 通过亲和筛选获得的TPO模拟肽和功能筛选获得的非肽类模拟物均具有刺激巨核细胞增殖、成熟和增加血小板数目的功能,而且两者体外的生物活性均与TPO相当。
Aliskiren as a new non-peptide renin inhibitor is more effective in blocking RAS system than ACEI, ARB in theory. 阿利吉仑作为新型非肽类肾素抑制剂,理论上比ACEI,ARB类药物更能有效阻断RAS系统,从而有希望进一步改善胰岛素抵抗。
Venom is mixture consisting of the various peptides, enzymes and other non-peptide, which melittin is the main active component of bee venom. 蜂毒由各种肽类、酶类及其他非肽类组份混合而成,其中蜂毒肽(Melittin)是蜂毒的主要活性成分。
Losartan was an efficient oral antihypertensive drug that producted by the United States DuPont-Merck pharmaceutical company in 1994. It was the first non-peptide angiotensin ⅱ receptor blockers which can be easily accepted by patients with safe and effective. 洛沙坦是一种易被患者接受的口服安全有效的高效降压药物,是由美国杜邦-默克制药公司在1994年开发的第一个非肽类血管紧张素Ⅱ受体拮抗剂。