An important part of the cellular response to DNA damage is checkpoint activation& checkpoint kinases CHK1 and CHK2 phosphorylate key proteins to elicit cell-cycle blocks. 细胞对DNA损伤作出应答的一个重要过程是检查点活化(检查点激酶CHK1和CHK2使关键蛋白磷酸化,从而阻止正常的细胞周期。)
Aurora B is a chromosomal passenger protein. It can phosphorylate Histone H3 in mammals. protein. AuroraB是一个染色体伴随蛋白,它可以磷酸化哺乳动物细胞中的组蛋白H3。
It has been reported that PKB can phosphorylate GSK-3 and inhibit β-catenin protein degradation. 有文献报道PKB能磷酸化GSK-3并抑制其活性,进而抑制β-连环蛋白的降解。
However, both 0.1 mT and 0.4 mT power frequency magnetic fields could not phosphorylate ( activate) the MKK3/ MKK6, which is a general upstream kinase of P38 MAPK. 但2个强度都不能诱导上游激酶MKK3/MKK6的磷酸化(活化)。一、在灭菌处理和未灭菌处理中,C。
The JAKs are associated with the receptors and activated following ligand binding. The activated JAKs phosphorylate both themselves and the receptor subunits, and through SH2-containing proteins activate the ras pathway. 造血生长因子与受体结合后激活JAK,JAK发生自我磷酸化的同时也使受体磷酸化,继而通过SH2蛋白激活ras通路。
Protein Tyrosine Kinase ( PTK) is a kind of kinase which exists in cellular membrane or cytoplasm. Having typical carboxyl-terminal, PTK can phosphorylate downstream molecules and also phosphorylate itself. 酪氨酸蛋白激酶(ProteinTyrosineKinase,PTK)是存在细胞膜或细胞浆中的蛋白激酶,它具有典型的羧基端催化区,当被激活后可以将其底物以及自身的酪氨酸残基磷酸化。
Activated PKB can phosphorylate many cellular proteins, and adjust metabolism and transport of glucose, gene transcription, protein synthesis, cell apoptosis. 活化的PKB可以使多种底物磷酸化,从而调节糖代谢与转运、基因转录、蛋白质的合成和细胞凋亡等重要生理过程。
The hexokinase is an enzyme to phosphorylate six-carbon sugar, especial glucose. 己糖激酶是一个磷酸化6-碳糖的酶,特别是葡萄糖。
PKA is a serine/ threonine kinase, and it can phosphorylate the serine residues and the threonine residues of the target protein. PKA作为丝/苏氨酸激酶,可令其靶蛋白的丝氨酸或苏氨酸残基磷酸化。