The increased of plasma norepinephrine may participating the pathophysiology of portal hypertension or exasperating portal hypertension in cirrhosis. Our results support the use of α-receptor blockers to decreased PVP and PVR for treatment and phylaxis of bleeding due to esophageal variceal rupture in cirrhosis. 提示肝硬化时血浆去甲肾上腺素的增加可能参与门脉高压症的某些病理生理过程,并进一步支持用a受体阻滞剂降低门脉压力和门脉血管阻力,治疗肝硬化食道静脉曲张破裂出血或预防出血。