Pimaricin exhibits broad spectrum antifungal activity against yeast and filamentous fungi by binding specifically to ergosterol to block fungal growth. 那他霉素具有广谱的抗真菌活性,能抗酵母和丝状真菌,通过结合特定的麦角固醇抑制真菌的生长。
Unlike the related polyenes, nystatin and filipin, pimaricin does not change the permeability of the plasma membrane. 不像相关的聚烯类、利霉菌素和非律平,那他霉素不能改变质膜的通透性。