Sivelestat sodium was synthesized from pivaloyl chloride via esterification, acyl chloridization amidation, debenzylation, and then salt formation. The reaction conditions were improved and the total yield was 47.9%. 以新戊酰氯为原料,经酯化、酰氯化、酰胺化、脱苄基,与氢氧化钠成盐制成西维来司钠,1,经工艺改进,多步收率有较大提高,总收率47.9%。
Selectivity of Monochlorination of Pivaloyl Chloride Utilizing Total Reflux Packed Column 特戊酰氯在全回流填料塔内一氯化反应选择性的研究
The N of indole-3-propionic acid is protected by pivaloyl chloride, and then thionyl chloride and aluminum chloride for acylation cyclization. 2. 用特戊酰氯对吲哚-3-丙酸上的N进行保护,然后用氯化亚砜和三氯化铝进行酰化反应关环。