New Advances of Polymyxins in the Treatment of Pan Drug Resistant Gram-negative Bacterial Infections 多粘菌素对泛耐药革兰阴性杆菌严重感染临床应用新进展
The global emergence of multidrug-resistant gram-negative bacilli has spurred a renewed interest in polymyxins. 全球多重耐药的阴性杆菌出现,使粘菌素类重新起作用。
Thus, there is an urgent need for the development of novel analogs of polymyxins with less acute toxicity or other new antibiotics against MDR Gram-negative bacteria. 因此,非常有必要加快开发高效、低毒的新型多粘菌素结构类似物或其它新药,以应对日益严重的革兰氏阴性细菌耐药性问题。