Gabapentin and pregabalin for the treatment of neuropathic pain: A review of laboratory and clinical evidence. 加巴喷、普瑞巴林用于治疗神经痛:实验室和临床实验数据的回顾。
Pregabalin was administered either intraperitoneally ( IP) or intrathecally ( IT) and dosed up incrementally until an antiallodynic effect without sedation or motor impairment was apparent. 普瑞巴林通过腹膜内或鞘内给药剂量逐渐增加直到产生抗痛觉超敏作用或出现运动受损。
The physical property of pregabalin and six different synthetic routes for preparing pregabalin starting with 4-methyl valeric acid and isovaleraldehyde were introduced separately. 介绍普瑞巴林的物理性质及其6种分别以4-甲基戊酸和异戊醛为原料的不同合成方法。
Pregabalin has good prospects on treating central sensitization but less been used in the treatment of migraine. 普瑞巴林作为具有良好前景的中枢敏感化治疗药物,应用于偏头痛的治疗较少。