Mutations in the presenilin genes are the main cause of familial Alzheimer's disease. 早衰蛋白基因的变异是家族性阿尔茨海默病的主要病因。
Objective To explore the effect of mutation of presenilin 1 ( PS 1) gene on the pathogenesis of familial Alzheimer disease ( FAD). 目的探讨早老素1基因突变在家族性阿尔茨海默病(FAD)发病中的作用。
Genetic association between presenilin 1 polymorphism and late onset Alzheimer ′ s disease 早老素1基因多态性与迟发性阿尔茨海默病的遗传相关研究
The effects of beta-amyloid protein and presenilin on potassium channel 淀粉样蛋白及早老素对钾通道的影响
Mutations in presenilin 1 gene 、 presenilin 2 gene and amyloid precursor protein gene could change normal metabolism of amyloid precursor protein and lead to overproduction of A β. 早老蛋白和淀粉样沉淀前体蛋白基因的突变均能改变淀粉样沉淀前体蛋白的正常切割,使得Aβ的生成量增加。
The Presenilin ( PS) gene polymorphism is closely associated with Alzheimer's disease. 早老素蛋白(presenilin.PS)的基因多态性与阿尔茨海默病(Alzheimer'SDisease,AD)发病关系密切。
Novel presenilin 1 mutation ( S170F) causing Alzheimer disease with lewy bodies in the third decade of life 早老素1基因新突变(S170F)导致21~30岁发病伴lewy体的阿尔茨海默病
The Study Advances of Presenilin Gene and Notch signaling 早老素与Notch信号系统的研究进展
Objective To detect the expressions of human epidermal growth factor receptor 2 ( Her-2), epidermal growth factor receptor ( EGFR), presenilin 2 ( PS-2) and estrogen receptor ( ER) in breast cancer and discuss their clinical implications. 目的探讨人表皮生长因子受体2(Her-2)、表皮生长因子受体(EGFR)、雌激素调节蛋白(PS-2)、雌激素受体(ER)在乳腺癌中的表达及其临床意义。
Analysis of the interaction of the polymorphisms of presenilin 1 gene and ApoE gene in Alzheimer's disease 阿尔茨海默病患者早老素-1基因与ApoE基因关联分析
To explore the mechanism of presenilin mutation causing Alzheimer's disease and to provide the evidence for the prevention and treatment of AD. 探索早老素突变导致AD的机制,为疾病的预防和治疗提供依据。