prion

noun

1. 普利子，传染性蛋白质粒子，朊病毒（能导致脑病）
   a very small unit of protein that is believed to be the cause of brain diseases such as BSE , CJD and scrapie

1. Known as a "prion" this mysterious protein lies at the heart of the 1996 British BSE ( Bovine Spongiform Encephalopathy) crisis.
   这种名为普里安的神秘蛋白质已成为1996年英国牛海绵状脑病（BSE）危机的关注中心。
2. After purification and refoldation of the recombinant OvPrPC, conformational changes of ovine prion protein was triggered by thermal denaturation.
   并在热力学因素的作用下，研究了重组绵羊朊蛋白的构象转化。
3. The foundation of Protein A magnetism to detect Prion assay
   ProteinA磁珠检测朊病毒方法的建立
4. Stable Expression of Bovine Prion Protein in CHO/ dhfr-cells
   牛朊蛋白在CHO/dhfr-细胞中的稳定表达
5. However, prion diseases are considered to be representative of other protein precipitation-associated diseases.
   然而，阮病毒疾病被认为是其他蛋白相关疾病的典型。
6. They occur when normal prion proteins become knotted and resistant to being broken down, and cause rapid brain degeneration that is inevitably fatal.
   当正常的朊病病毒多节化并具有了抗破坏能力的时候，这些疾病开始出现；接着导致不可避免的致命的迅速脑部恶化。
7. Stable inhibition of human prion protein through a retrovirus-based RNAi system
   利用RNAi逆转录病毒载体系统对人朊病毒蛋白表达的稳定抑制
8. Physico-Chemical Property and Polyclonal Antibody Production of Bovine Prion Protein
   牛朊蛋白理化性质分析及其多克隆抗体的制备
9. It is this altered prion protein that is proposed as part or all of the infectious agent.
   这就是被看作病原体的部分或全部的、变异的普利昂蛋白。
10. Cloning and sequence analysis of prion protein gene in African lion
    非洲狮朊蛋白基因的克隆与序列分析
11. The origin of the crisis was the feeding of cattle with animal feed that was contaminated by a new pathogenic agent-a prion.
    这场危机起源于使用动物饲料喂养牛，这些动物饲料都被一种新的致病体&朊蛋白污染了。
12. Considering the long incubation times and often sporadic nature of prion diseases, this may be prudent but is still a topic of some discussion.
    考虑到长时间的孵育时间和自然散在发生的阮病毒疾病，这个还是需要谨慎的，而如何灭活阮病毒仍然是讨论的焦点。
13. In this course, the molecular and biochemical basis of the prion diseases, which include bovine spongiform encephalopathy, Creutzfedt-Jakob disease and kuru will be examined.
    在本课程中，我们将分析包括了牛海绵体样脑病，克雅氏症，以及库鲁病的朊蛋白疾病的分子和生化致病基础。
14. Effect of Prion Protein on Autophagy and It's Possible Mechanism
    朊病毒蛋白对细胞自噬的影响及可能的作用方式
15. Surgeon or Designee will notify the Operating Room of the brain biopsy of suspected prion disease.
    外科医生或操作者应通知可疑朊毒体病人进行脑组织活检的手术室。
16. The evidence is accumulating that prion diseases are due to proteins which change their conformation irreversibly during an association reaction, perhaps by mechanisms related to amyloid accumulation.
    越来越多的证据指出蛋白感染素疾病（如狂牛病）是因为蛋白质结合过程中其构型产生不可逆的改变，可能是由类淀粉体堆积相关的机制造成。
17. What is even more peculiar: exactly the same prion proteins occur in healthy animals.
    更奇特的是：这种蛋白质在健康动物中也存在。
18. "One interpretation was that we had made a terrible mistake and that PrP had nothing to do with prion diseases," Prusiner said later.
    后来，普鲁辛纳说：一个解释是，我们犯了一个可怕的错误，PrP与普里安疾病毫无关系。
19. In this thesis, we studied the formation and degradation of protein amyloids related to two kinds of amyloid diseases, prion diseases and Alzheimer's disease.
    本论文有两个主轴，分别在探讨普昂疾病与阿兹海默症两种类淀粉疾病之致病类淀粉蛋白的形成与分解。
20. Surprisingly, according to the new research, wires coated with uninfected brain homogenate could also initiate prion disease in cell culture, which was transmissible to mice.
    令人惊讶的是，根据这项新的研究，用未感染过的脑组织均浆包被的金属丝也能够在细胞培养中引发感染性朊蛋白疾病，并可使小鼠感染。
21. Molecular cloning and the sequences analysis of the prion protein gene in Amur tiger
    东北虎朊病毒基因的克隆与序列分析
22. Study on Detection of Prion Protein Based on Surface Plasmon Resonance Technology
    基于表面等离子共振（SPR）的朊蛋白检测技术研究
23. But the news is bittersweet& the high proportion of cells that must be treated with RNAi before seeing a beneficial effect means the approach is a long way from a cure for prion diseases in humans.
    但是这个消息却是喜忧参半，高比例的细胞必须在发现有益效果之前进行RNA干预治疗，也就是说在人身上治愈朊病病毒将是一个漫长的过程。
24. Analysis on Polymorphisms of the Prion Protein Gene in Local Sheep Species of Inner Mongolia, China
    内蒙古地方品种绵羊朊蛋白基因多态性分析
25. However, the prion protein in scrapie-infected brain tissue differs from normal prion protein in some of its properties.
    然而，在感染羊瘙痒病的大脑组织的普利昂蛋白在某些性质上不同于一般的普利昂蛋白。
26. Can the "flipped" BSE priori induce the normal human prion to flip?
    这种变形的BSE普里安能诱发正常人普里安发生改变吗？
27. Effect of the thermodynamic factor on conformational conversion of the ovine prion protein in vitro
    热力学因素对绵羊重组朊蛋白体外构象转化的作用
28. Could RNA interfere with prion disease?
    RNA能否干预普粒子疾病？
29. It is not a prion disease. It is seldom fatal to animals and is rarely transmissible to humans.
    口蹄疫不是由朊病毒引起的病，很少对动物有致命性，也很少传染给人。

noun

1. (microbiology) an infectious protein particle similar to a virus but lacking nucleic acid