Bioinformatics, cloning and expression of a novel proteasome α 2 gene from Clonorchis sinensis 华支睾吸虫蛋白酶体α2新基因的生物信息学分析与克隆表达
Intracellular ATP Concentration Determines the Sensitivity of Cell Death Induced by Proteasome Inhibition 细胞内ATP浓度决定蛋白酶体抑制诱导细胞死亡的敏感性
Inhibition of Proteasome to Disrupt Unfolded Protein Response and Autophagy in Multiple Myeloma Cells 抑制蛋白酶体干扰骨髓瘤细胞未折迭蛋白反应与自噬
Cancer-causing mutations can also activate the proteasome, so drugs that block protein breakdown, such as nelfinavir, could theoretically halt both diseases. 变异的癌症细胞也可以激活蛋白酶体,像那非那韦之类阻断蛋白分解的药物,理论上可以治疗癌症。
Proteasome inhibitor MG-132 reverses acquired resistance to TRAIL in human colon cancer cells 蛋白酶体抑制剂MG-132逆转人结肠癌细胞获得性TRAIL耐药
Here, we discuss the molecular mechanisms that link autophagy and the proteasome system, as well as the emerging roles of ubiquitin and ubiquitin-binding proteins in selective autophagy. 在本文中,我们讨论了那些与细胞自噬以及蛋白酶体系统相关联的分子机制,并讨论了在选择性自噬作用中,泛素与泛素结合蛋白的新兴作用。
Inhibition of proteasome has been emerging as a promising approach in pathway-directed cancer therapy. 蛋白酶体的抑制在肿瘤的信号通路定向治疗方面已经成为一个极其有希望的途径。
Effect of the proteasome inhibitor MG-132 on hyperoxic lung injury and its mechanism in rats 蛋白酶体抑制剂MG-132对高氧肺损伤的影响及其机制
Molecular Docking of Proteasome Inhibitors from Plant 植物源蛋白酶体抑制剂的分子对接研究
A Pilot Study on Effects and Mechanisms of Action of Proteasome Inhibitors on t ( 8; 21) Leukemia 蛋白酶体抑制剂对t(8;21)白血病的作用及分子机制实验研究
Proteasome Inhibition by Bortezomib in the Regulation of NK Cell Survival and Function 蛋白酶体抑制剂对自然杀伤细胞活性和功能影响的研究
"Malignant myeloma cells hae higher proteasome concentrations than their normal counterparts, plasma cells, which are involved in the antibody production and are part of the immune system," he added. “恶性骨髓瘤细胞的蛋白酶体浓度比正常浆细胞高。浆细胞参与抗体产生,是免疫系统的一部分。”他补充说。
Effects of Proliferation and Apoptosis of Gastric Carcinoma Cell Line SGC-7901 by Proteasome Inhibitor MG-132 蛋白酶体抑制剂MG-132对胃癌SGC-7901细胞增殖和凋亡的影响
"The proteasome is the most important regulator of the concentration of several cellular proteins which are involved in cell cycle regulation and in programmed cell death," senior investigator Dr. 蛋白酶体是一些参与细胞周期调控和程序性细胞死亡的细胞蛋白浓度的最重要的调节者。
Recently, it has become clear that the controlled and timed destruction of the proteins plays an essential role in cell cycle regulation and the26S proteasome is involved in the destruction. 最近,这些蛋白的可控性和程序性破坏在细胞周期调控中所起的作用的机理也越来越清楚,并且26S蛋白酶体与蛋白的破坏有关。
The proteasome inhibitor MG-132 can reduce the lung injury induced by hyperoxia and inhibit P38MAPK signaling pathway. 蛋白酶体抑制剂MG-132可以减轻高氧引起的肺损伤,可能对p38MAPK信号通路有抑制作用。
The proteasome is an abundant multi-enzyme complex that provides the main pathway for degradation of intracellular proteins in eukaryotic cells. 蛋白酶体是真核细胞中含量丰富的多酶复合物,它主要协助降解细胞内的蛋白。
Classification and synthesis of ubiquitin-proteasome inhibitor Progress on Organic-Metal Complexes as Proteasome Inhibitor 泛素-蛋白酶体及其抑制剂的分类与合成金属配合物作为蛋白酶体抑制剂的研究进展
The Ubiquitin/ 26S Proteasome Pathway and the Function in Plant Development 泛素/26S蛋白酶体途径及其在植物生长发育中的功能
Increasing evidence has identified a correlation between this protein and the proteasome, the cellular proteolytic machinery, in particular the ubiquitin – proteasome system. 越来越多的研究表明了这种蛋白与蛋白酶体&细胞内蛋白酶机械,特别是泛素-蛋白酶体的相关性。
Study between related factors of hepatocellular carcinoma and ubiquitin proteasome pathway 肝细胞癌相关因子与泛素-蛋白酶体通路关系的研究
Only few data are reported on the use of proteasome inhibitors in this subset of patients. 蛋白酶体抑制剂在这类患者中的使用几乎没有报道。
The proteasome is an abundant, catalytic complex that is found in both the nucleus and cytoplasm of eukaryotic cells. 蛋白酶体是存在与真核细胞的细胞核和细胞质中的含量丰富且有催化作用的复合物。
The expression of ubiquitin and proteasome proteolytic activity in gastric cancer and adjacent tissues 泛素表达和蛋白酶体活性在胃癌及癌旁组织中的研究
Proteomic Characterization of Human Erythrocyte 20S Proteasome and Analysis of Species-dependent 20S Proteasome Heterogeneity Diphtheria antitoxin is a foreign protein. 人红细胞20S蛋白酶体的蛋白质组学表征及不同来源20S蛋白酶体异质性的研究白喉抗毒素是异性蛋白。
NOB1 is a newly found gene regulating the function of the26S proteasome, cell cycle and gene transcription. NOB1基因是新发现的一个与细胞周期及转录调节有密切关系的基因。
The Study of Association of Anti-inflammatory Effects of Shikonin with Its Proteasome Inhibition 左旋紫草素抗炎作用与其抑制蛋白酶体活性关系的研究
Furthermore, the altered proteasome functionality is not associated with a decrease in cell viability, but is linked with increased levels of protein oxidation. 另外,可变的蛋白酶体功能与细胞活力下降无关,而与蛋白氧化水平的升高有关。