Puromycin is non-selective, inhibiting RNA blocking ribosomal translation. 嘌罗霉素没有选择性,抑制RNA阻止核糖体的翻译。
Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. 氨基核苷嘌呤霉素是合成嘌呤毒素的半合成类似物中关键性的中间体。
Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing expression of integrin expression in cultured glomerular epithelial cells. 氨基核苷嘌呤霉素诱导肾病变是人原发性肾病综合症的模型,抑制培养的肾小球上皮细胞整联蛋白的表达。
The Protective Mechanism of Dexamethasone in Puromycin Injuried Mouse Podocyte Cell Line 地塞米松对嘌呤霉素损伤小鼠肾小球足细胞系保护作用的分子机制研究
Puromycin dihydrochloride has been formulated as a salt to achieve higher water solubility. 为提高其水溶性,二盐酸嘌呤霉素设计成其盐的形态。
While the salt shares the same pharmacological properties as puromycin free base, its greater water solubility may offer advantages in some in vitro applications. 该盐同嘌呤霉素游离碱具有相同的药理学性质,它的高度的水溶性能给体外研究应用提供一些优势。
Puromycin is used in cell biology to select mammalian cell lines that have been transformed by vectors that express puromycin-N-acetyl-transferase. 在细胞生物学中用嘌罗霉素来选择用载体转化能表达嘌呤霉素-N-乙酰基转移酶类的哺乳动物细胞系。
We tested these possibilities utilizing the puromycin aminonucleoside ( PAN) model of renal injury in immortalized mouse podocytes. 我们利用氨基核苷嘌呤霉素(PAN)肾脏损伤模型在小鼠永生足细胞中检验了这些可能性。
Comparison between pyrogallol red-molybdate method and biuret colorimetric assay for determining the total urine protein in puromycin aminonucleoside-treated rats 邻苯三酚红钼络合法与双缩脲比色法测定嘌呤霉素肾病大鼠尿中总蛋白浓度的比较
Methods: Puromycin aminonucleoside ( PAN) nephrosis was established. 方法:建立嘌呤霉素(PAN)大鼠肾病模型,用体视学方法检测足突形态改变;
The antibiotic-resistant transfected cells were selected and enriched by applying puromycin in culture medium. 采用嘌呤霉素筛选和富集转染具有抗性的细胞。
Methods: Effect of AAM was observed in puromycin amino-nucleoside induced nephrotic syndrome model of rat, and pravachol, an effective lipid lowering medicine, was used as Positive control. 方法:采用嘌呤霉素引起的肾病综合征大鼠模型,以有效的降脂药普伐他汀作阳性对照,观察黄芪当归合剂的作用。
Methods: Chronic nephrosclerosis model rats induced by repeated intraperitoneal injection of puromycin were randomly divided into the model group, AAM group and Irbesartan ( an antagonist of angiotensin) group. 方法:采用大鼠慢性嘌呤霉素肾硬化模型,随机分为模型组,黄芪当归合剂治疗组(简称中药治疗组),血管紧张素受体拮抗剂(Irbesartan)治疗组(简称AT1RA组)。
Correlation between urinary protein excretion and morphometric changes of glomerular foot process in rats with puromycin aminonucleoside nephropathy 嘌呤霉素肾病鼠尿蛋白量与足突形态改变的关系
Therapeutic effect of a new liposome-prednisolone on the puromycin aminonucleoside nephropathy in rats 泼尼松龙新型靶向脂质体制剂对嘌呤霉素氨基核苷肾病的疗效
Expression of fractalkine in rats with puromycin aminonucleoside nephropathy 不规则趋化蛋白在嘌呤霉素氨基核苷肾病模型中的表达
The effects of actinomycin D and puromycin on the mediation of cellular immunity by S180 ascitic tumor cell-specific iRNA were investigated. 以[~3H]Leu-LAI为指标,观察放线菌素D和嘌呤霉素对小鼠S(180)腹水瘤细胞特异性iRNA体外转移细胞免疫活性的影响。
Morphometric analysis of glomerular foot process in puromycin aminonucleoside nephropathy in rats 嘌呤霉素肾病鼠足突形态改变的形态计量学研究
Results Stable express cells were obtained by puromycin selection. 结果经嘌呤霉素筛选得到稳定表达细胞株;
Objective: To investigate the morphometric changes in the podocyte foot process during the development of, and recovery from, acute puromycin aminonucleoside ( PAN) nephropathy in rats. 目的:定量研究嘌呤霉素肾病大鼠模型从建立到恢复过程中,足突的形态变化规律。
Astragalus and Angelica retard the progressive tubulointerstitial lesions in puromycin nephropathy 黄芪当归合剂防治肾病综合征鼠进行性肾小管间质损伤
Objective: To investigate the effects of Chaihuang-Yishen Formula Extract ( CYE) on urinary protein and the function of fibrinolysis of rats with nephrosis induced by puromycin aminonucleoside ( PAN). 目的探讨柴黄益肾方提取物(CYE)对嘌呤霉素氨基核苷(PAN)肾病大鼠尿蛋白及纤溶功能的影响。
Objective: To investigate the possible role of nephrin in the development of proteinuria in rat with puromycin aminonucleoside ( PAN) nephropathy. 目的:观察nephrin在大鼠氨基核苷嘌呤霉素肾病模型(PAN)中的表达变化,探讨其在蛋白尿发生中的作用。
Expression and implication of tissue transglutaminase in FSGS model rats with puromycin aminonucleoside nephropathy 组织型转谷氨酰胺酶在局灶节段性肾小球硬化大鼠肾脏中的表达和意义
The sensitivity test of puromycin defined the least concentration that resists cell growth. 通过嘌呤霉素敏感试验确定了抑制HEK293细胞生长的最低浓度。