Raloxifene prevents breast cancer and does not increase the risk of uterine cancer, she added. 用雷洛昔芬预防乳腺癌,不会增加子宫癌风险,她补充说。
Methods: 36 cases of postmenopausal osteoporosis were collected and divided into two groups, which were randomly divided into two groups: raloxifene group and alendronate group. 方法:将36例绝经后妇女骨质疏松症患者分为他莫昔芬治疗组和阿仑膦酸钠治疗组,运用药物经济学原理进行成本-效果分析。
Because no cardiovascular benefit was observed in the study, raloxifene should not be used for the primary or secondary prevention of cardiovascular disease. 在研究中,因为没有观察到心血管方面的好处,所以雷洛昔芬不应是首选或次选的预防心血管疾病的药物。
Despite this risk, tamoxifen and another drug in this class, raloxifene, remain an extensively used and popular treatment. 虽然存在这些副作用,三苯氧胺和另一种同类药物-雷洛西芬已经被广泛用于乳腺癌的治疗。
Conclusion: Alendronate is more reasonable and economical than raloxifene in treating postmenopausal osteoporosis. 结论:应用阿仑磷酸钠治疗绝经后妇女骨质疏松症较他莫昔芬更为合理、经济。
However, researchers showed that raloxifene in combination with systemic oestrogen results in an increase in hyperplasia, she said. 然而她说,研究人员指出,雷洛昔芬的全身雌激素效应会导致异常增生增加。
Objective To synthesize raloxifene hydrochloride, which is a selective estrogen receptor modulator. 目的合成选择性雌激素受体调节剂盐酸雷洛昔芬。
Raloxifene is indicated for the treatment and prevention of osteoporosis in postmenopausal women. 雷洛昔芬是用来预防和治疗绝经后妇女的骨质疏松症的。
A relatively higher incidence of polyps occurred in the raloxifene group ( 4.7%). 雷洛昔芬治疗组的息肉发生率相对较高(4.7%)。
Objective: To investigate the effect of raloxifene, a selective estrogen receptor modulator, on blood pressure, lipid, fibrinogen and estrogen receptor in ovariectomized rats. 目的:探讨选择性雌激素受体调节剂雷洛昔芬对去卵巢大鼠血压、血脂、纤维蛋白原和雌激素受体的作用。
Effect of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis 盐酸雷洛昔芬对绝经后骨质疏松妇女骨密度、骨代谢生化指标和血脂的影响
Effect of selective estrogen receptor modulator raloxifene on estrogen responsive element transcriptional activity in vascular endothelial cells 雷洛昔芬对血管内皮细胞雌激素应答元件转录活性的影响
Raloxifene: a selective estrogen receptor mediator 雷洛昔芬&选择性雌激素受体调节剂
Changes of bone metabolic biochemical markers one year after applying raloxifene hydrochloride in healthy postmenopausal women 健康绝经后妇女应用盐酸雷洛昔芬1年后骨代谢生化指标的变化
The HPLC method for determination related substances of raloxifene hydrochloride raw medicine are established. 建立了盐酸雷洛昔芬原料药有关物质的测定方法。
Methods: 2,3-dihydro-6-chloro-4H-1-benzopyran-4-phenylhydrazone ( 1) was designed and synthesized on basis of review of raloxifene and ipriflavone. Its benefit effects on postmenopausal osteoporosis and cardiovascular system were studied by cell culture method. 方法:在综合考察雷洛昔芬和依普黄酮的基础上,设计合成了2,3二氢6氯4H1苯并吡喃4苯腙(1),并在细胞水平考察其对骨和心血管系统的保护作用。
Conclusions Certain concentrations of raloxifene ( 10-8 M, 10-7 M) could inhibit IL-1 β and IL-6 secretion in rat osteoblasts and was able to affect the function of osteoclasts through modulating the autocrine and paracrine function of osteoblasts. 结论适当浓度下雷洛昔芬(10-8M,10-7M)抑制大鼠成骨细胞分泌IL-1β和IL-6,雷洛昔芬能够通过调节成骨细胞的自分泌及旁分泌影响破骨细胞的功能。
The effect of raloxifene on cardiac autonomic regulation in osteoporotic women 雷洛昔芬对骨质疏松妇女心脏自律性的影响
Effects of hormone replacement therapy or raloxifene on ambulatory blood pressure and arterial stiffness in treated hypertensive postmenopausal women 已治疗的绝经后高血压妇女中激素替代治疗或雷诺昔酚对动态血压和动脉僵硬度的作用
Effects of Raloxifene on cytokine secretion in osteoblasts in rats 雷洛昔芬对大鼠成骨细胞分泌细胞因子的影响
Evaluation of raloxifene safety 雷洛昔芬的安全性评介
So the Raloxifene could protect metabolism of bone and lipid, possibly due to its estrogen-like effect. 结果提示,Raloxifene能提高卵巢切除大鼠骨密度,降低骨转换,保护脂代谢,提高雌激素水平,可能与其拟雌激素样作用有关。
Methods A total of 48 female Sprague-Dawley rats were divided into 4 groups: the sham-operated group ( 12 rats), the ovariectomized group ( 12 rats), the estrogen group ( 12 rats) and the raloxifene group ( 12 rats). 方法选择3月龄Sprague-Daw-ley雌性大鼠48只,随机分为假手术组、去卵巢组、雌激素组及雷洛昔芬组,每组12只,给药3个月后处死大鼠。
Aim To synthesize 6-methoxy-2-( 4-methoxyphenyl) benzothiophene which is an important intermediate for synthesis of raloxifene hydrochloride. 目的合成盐酸雷洛昔芬关键中间体6甲氧基2(4甲氧苯基)苯并[b]噻吩。
Effect of raloxifene on bone metabolism and uterine wet weight and endometrium of uterus in ovariectomized rats 雷洛昔芬对大鼠去势后骨质疏松及子宫内膜的影响
Results The bone desity increased after raloxifene treatment, the expression of ERa mRNA elevated, ER β mRNA showed no significant increase. 结果雷洛昔芬使去卵巢大鼠骨密度增加,提高ERαmRNA,对ERβmRNA的表达无明显的影响作用。
A double blind, randomized, placebo-controlled study for raloxifene hydrochloride in prevention and treatment of menopausal osteoporosis 盐酸雷洛昔芬防治绝经后骨质疏松症随机双盲对照研究
Effect of raloxifene and estradiol on the biological function and osteoprotegerin expression of osteoblasts in vitro 雌二醇与雷洛昔芬对体外培养成骨细胞生物学功能的影响及护骨素表达的调控
Raloxifene is also used in prevention and treatment of osteoporosis in postmenopausal women. 雷洛昔芬还被用于防治绝经后妇女骨质疏松症。
There is also evidence showing that raloxifene has estrogen agonistic activity on dopamine receptor in the central nervous system. 有证据显示,raloxifene在中枢神经系统的多巴胺受体上具有雌激素激动剂的活性。