Effect of poly ( lactide-co-glycolide acid)/ nerve growth factor composite scaffold implantation on remyelination in a rat model of spinal cord injury 乙交酯-丙交酯共聚物/神经生长因子复合支架植入大鼠损伤脊髓后的髓鞘再生
Hepatocyte growth factor modified human umbilical cord mesenchymal stem cell therapy promotes remyelination after intracerebral hemorrhage in rats 转肝细胞生长因子的脐带间质干细胞移植促进大鼠脑出血后髓鞘再生
The morphological changes include degeneration, loss, regeneration of myelinated nerve libers accompanied by segmental demyelination and remyelination, degeneration and regeneration of unmyelinated nerve fibers and microangiopathy. 病理表现不一,主要为有髓神经纤维变性、丢失、再生伴节段性脱髓鞘与复髓鞘,无髓神经纤维变性伴大量再生以及微血管病变。
Effects of aescine on content of serum MBP and remyelination of ischemic focus in rats of ischemical stroke 七叶皂苷对缺血性脑卒中大鼠血清MBP含量和髓鞘再生的影响
Conclusions EAE is characterized by perivascular inflammatory cell infiltration and demyelination in white matter and some remyelination. 结论EAE的病理改变为血管周围炎性细胞浸润、白质脱髓鞘及髓鞘重建。
At the 8th week after the treatment, the tissue response to the scaffold, degradation of the scaffold, glial scar, migration and differentiation of the neural stem cells, and regeneration and remyelination of the axons in the injured region were observed. 8周后观察支架的组织反应、降解情况及神经干细胞的迁移分化和脊髓轴突再生情况。
These results suggest that block Lingo-1 signal can promote remyelination and facilitate the electrophysiological recovery in the CNS demyelination diseases and the anti-Lingo-1 antibody may serve as a potential therapy to enhance myelin repair following CNS injury and diseases. 上述结果提示在CNS脱髓鞘病变中阻断Lingo-1信号可以促进髓鞘再生和电生理功能的恢复,抗-Lingo-1抗体可作为一种有效的治疗药物用于CNS脱髓鞘病变的治疗。
The pathologic change is an axonal neuropathy characterized by segmental de/ remyelination and a reduction in nerve fibers. APN的病理变化主要表现为轴突的病变,伴有节段性的脱髓鞘和髓鞘再生以及神经纤维的减少。