MicroRNAs ( miRNA) are a new class of noncoding RNAs, which are encoded as short inverted repeats in the genomes of animals and plants. 微RNA是新发现的一类非编码RNA分子,在动植物细胞中广泛表达,它的基因是短的反向重复序列。
Development of the role of microRNAs regulation in osteogenesis 成骨过程中微小RNAs调控作用的研究进展
Analyses indicate that part of the cell response to the accumulation of misfolded proteins is the production of several micro-RNAs, small molecules that regulate gene expression. 分析结果显示,细胞在累积错误折叠蛋白的部位产生了一些微小RNAs,是一些能够调控基因表达的小分子。
Perhaps the ancestral role of guide RNAs that direct U insertion and deletion in the related kinetoplastid protozoa was to provide a template scaffold to link modules. 或许,与动基体目原生动物有亲缘关系的原生动物体内的引导尿嘧啶插入及缺失的指导RNA的古老作用就是为模块的连接提供一个模板支架。
Prediction of the microRNAs related to cardiovascular diseases by bioinformatics 用生物信息学方法预测与心血管疾病相关的微RNAs
Objective To explore and identify the non-coding RNAs related to tumors. 目的寻找并验证与肿瘤相关的非编码RNA。
Epigenetics: advances of non-coding RNAs regulation in mammalian cells 表观遗传学:生物细胞非编码RNA调控的研究进展
Progress of Plant Small RNAs and Their Roles in Stress Resistance 植物小RNAs及其抗胁迫机制研究进展
The present invention is directed to nucleic acid molecules and nucleic acid constructs, and other agents associated with simultaneous up-and down-regulation of expression of RNAs. 本发明涉及核酸分子和核酸构建体,以及其它与RNA表达的同时上调和下调有关的试剂。
Such small antisense RNAs may later have gained a role in RNA editing, possibly under selective pressure to repair a region or restore a reading frame after loss or erosion of a module. 之后,这些小的反义RNA可能会在RNA拼接中发挥作用,如在选择压力下修复基因组中一个区域,抑或在丧失或损坏一个模块后恢复一个读码框。
Ongoing studies have identified biochemical and nuclear mechanisms, genetic determinants, epigenetic factors and non-coding RNAs in the pathogenesis of diabetic complications. 正在进行的研究已经确定了生化和核机制,遗传因素,表观遗传因素在糖尿病并发症的发病机制中的非编码RNA。
Top row, three different RNA objects rendered from molecular computer models: from left, RNA antiprism composed of eight RNAs, a six-stranded RNA cube, and a10-stranded RNA cube. 上面一行是三个由分子计算机模型进行数据处理后获得的不同的RNA对象:左起分别为八个RNA组成的RNA反棱柱体、六链RNA立方体以及十链RNA立方体;
Core processes of epigenetic inheritance include DNA methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding RNAs. 核心过程的表观遗传的产业包括DNA甲基化、组蛋白改性、核小体重建、核染色质动力学和互动子都存在。
Cloning and Function Analysis of Viral Double-stranded RNAs Detected from the Infected Vicia faba 侵染蚕豆的双链RNA病毒的克隆及其功能分析
We now have a handle on being able to rationally modify micro RNAs to make them more efficient and possibly into therapeutic drugs. 现在有了具体的操作方法,使得我们能够合理修饰微小RNA使之更有效、并可能使之成为治疗药物。
Further analysis on the differential expression of these non-coding RNAs in tissues and development stages has been carried out, as well as their sequence features, conservation and functions. 同时,还对这些非编码RNA在不同组织和发育阶段的表达情况进行的检测,并对其序列特点,保守性和功能进行了深入分析。
The role of endogenous small RNAs in plant stress responses 内源小RNAs在植物胁迫反应中的作用
Small Interfering RNAs Specific for Spleen Tyrosine Kinase Inhibit Maturation of Dendritic Cells of Asthmatic Mice in Vitro RNA干扰靶向抑制酪氨酸蛋白激酶对哮喘小鼠树突状细胞功能的影响
Highly Efficient Inhibition on Replication of Grass Carp Reovirus Mediated by Chemically Synthesized Small Interfering RNAs 化学合成小干扰RNA分子高效抑制草鱼呼肠孤病毒复制
RNAi silences gene in a sequence-specific manner through the actions of small fragment of double-stranded RNAs. RNAi的机制是通过一段小片段双链RNA的作用序列特异性地使一段目的基因失活。
The mechanism existed in RNA interference, short RNAs, chromatin modification and chromatin silencing has been disclosed. 综述了RNA干扰,小RNA,组蛋白修饰,染色质沉默及基因表达调控之间存在着精密的网络调控机制。
I focus on the role of antisense RNAs in plasmid replication. 本文着重叙述反义RNA在质粒复制中的作用及其进展。
This not only demonstrates the existence of circulating HBV RNAs, but also provided a possibility for the detection of HBV RNA in sera. 这不仅证明了血清中HBvRNA的存在,而且提供了研究循环HBvRNA的常规PCR检测方法。
Methods Total RNAs of tumor tissues were extracted and were detected by RT-PCR. 方法提取肿瘤组织总RNA,用反转录聚合酶链式反应(RT-PCR)法进行检测。
Ten of chimeric RNAs were randomly picked for RT-PCR validation and four of them were verified. 3. 随机挑取了10个嵌合RNA进行RT-PCR验证,发现有4个能得到验证。
MicroRNAs ( miRNAs) are noncoding small RNAs which regulate gene expression at transcription and post-transcription level. MicroRNAs(miRNAs)是一类在转录和转录后水平调控基因表达的小RNA分子。
MicroRNAs ( miRNAs) are single-stranded, small and non-coding RNAs. microRNAs(miRNAs)是人和动物体内的单链非编码小RNA。
Based on the identification of replication and expression of HBV in these cells, the total RNAs extracted from these cells were hybridized with miRNA microarrays, and analyzed the expression profile of miRNAs. 在鉴定了HBV在上述三种细胞中的复制和表达情况的基础上,我们将从上述细胞中提取的总RNA与miRNA芯片杂交,检测miRNA在这些细胞中的表达水平。
The trans-encoded RNAs are the most extensively studied of the known non-coding RNAs. 在已知的非编码RNA中,对反式编码RNA的研究最为广泛。
RNA inference ( RNAi) is a conserved gene silencing mechanism characterized by the involvement of small RNAs. RNA干扰是一类保守的由小RNA参与的基因沉默机制。