Objective: To investigate the effect of rutaecarpine on the ventricular fibrillation threshold ( VFT) of isolated rat heart. 目的:研究吴茱萸次碱对离体大鼠室颤阈的影响。
Effect of Rutaecarpine on the Expression of Angiotensin C in Thoracic Artery of Hypertensive Rats 吴茱萸次碱对高血压大鼠胸主动脉血管肽酶C表达的影响研究
Determination of evodiamine and rutaecarpine of compound Wuzhuyu cataplasm in plasma by SPE-HPLC: Application to its pharmacokinetics SPE-HPLC测定复方吴茱萸巴布膏中吴茱萸碱和吴茱萸次碱血药浓度及药动学研究
Objective Extracting rutaecarpine from Evodia rutaecarpa which is the effective component in Evodia rutaecarpa and then optimum for the best industry extracting course. 目的用正交实验提取吴茱萸中有效成分吴茱萸次碱,优选吴茱萸的工业提取路线。
Result The experiment show that decoction time and menstruum dosage have the evidence influence on extracting rutaecarpine, and decoction hour take second place. 结果实验表明,煎煮次数、溶媒用量对吴茱萸次碱的提取影响较大,煎煮时间则次之。
Objective: To investigate the influence of different preparing processes on evodiamine and rutaecarpine. 目的:考察不同炮制工艺对中药吴茱萸中吴茱萸碱和吴茱萸次碱的影响。
Method To adopt the way of HPLC to determine the content of rutaecarpine which was extracted by using of water from Evodia rutaecarpa. Analysing the results of determination by using analysis of variance, and finding the best condition of extracting rutaecarpine. 方法采用HPLC法测定吴茱萸水提物中吴茱萸次碱的含量,测定结果进行方差分析,求出最佳条件。
Results and conclusions Six derivatives of rutaecarpine were synthesized with the structures confirmed by their()~ 1H-NMR and MS spectra. 结果与结论共合成6个未见文献报道的新化合物,它们的结构经1H-NMR和MS确证。
RESULTS Pretreatment with rutaecarpine ( 100 or 300 μ g · kg-1, i. v.) significantly reduced the infarct area and creatine kinase release as well as a significant increase in plasma concentrations of CGRP. 结果吴茱萸次碱(100、300μg·kg-1,iv)能显著缩小心肌梗死面积,降低血清CK水平,升高血浆CGRP浓度。
Synthesis and anti-platelet aggregation activities in vitro of rutaecarpine derivatives Rutaecarpine衍生物的合成及体外抗血小板聚集活性
Simultaneous determination of evodiamine and rutaecarpine in Evodia rutaecarpa ( juss) benth, and its processed products by RP-HPLC RP-HPLC法同时测定吴茱萸及其炮制品中吴茱萸碱和吴茱萸次碱
Result: The average recovery was 97.82% and 97.00%, the relative standard deviation was 0.81% and 1.10% for evodiamine and rutaecarpine respectively. 结果:测定组分具有较好的线性关系和分离度,两种生物碱的回收率分别为97.82%,97.00%,RSD分别为0.81%,1.10%。
Influence of rutaecarpine and Capsaicin on vascular contraction induced by anaphylaxis 吴茱萸次碱和辣椒素对过敏反应所致血管收缩的影响
Rutaecarpine Ameliorates Cerebral Ischemia-reperfusion Injury by Stimulating Calcitonin Gene-related Peptide Release in the Rat Brain 吴茱萸次碱促进脑组织降钙素基因相关肽释放减轻脑缺血-再灌注损伤
Determination of the Contents of Evodiamine and Rutaecarpine in 34 Species of Evodia Rutaecarpa by HPLC 34种吴茱萸中吴茱萸碱和吴茱萸次碱的含量测定
RESULTS: The material basis of the Wuzhuyu decoction was found to be produced chiefly by the chemical constituents contained in No. X 4, X 9 ( rutaecarpine), X 10 and X 12 chromatographic peaks. 结果:确定吴茱萸汤的药效物质基础主要为产生X4,X9,X10和X12号色谱峰中的化学成分(已确认X9为吴茱萸次碱)。
Research progress in pharmacological actions of evodiamine and rutaecarpine 吴茱萸碱和吴茱萸次碱的药理学研究进展
Study on Pharmacokinetics of Evodiamine and Rutaecarpine in Rabbit 吴茱萸碱和吴茱萸次碱在家兔体内的药动学研究
Protective effects of rutaecarpine on cardiac anaphylaxis 吴茱萸次碱对心脏过敏损伤的保护作用
METHODS: Evodiamine and rutaecarpine were extracted with the solvent ethyl acetate and the ultrasonic extractor. 方法:以乙酸乙酯为溶剂用超声震荡提取法提取吴茱萸碱和吴茱萸次碱。
The selective separation and extraction of rutaecarpine from E. rutaecarpa var. officinalis with the bulk liquid membrane and that of theanine from the tea water with tricaprylmethylammonium chloride-kerosene emulsion liquid membrane have been explored, respectively. 利用煤油整体液膜和三辛基甲基氯化铵-煤油乳状液膜对中药吴茱萸中的吴茱萸次碱和茶叶中的茶氨酸分别进行了选择性的分离提取,获得了优化的液膜体系。