Research on Expression of Landrace RXR α Gene on Different Days 不同日龄大白猪视黄素X受体α基因的表达研究
Experimental Researches of PPAR γ/ RXR α Targeting Treatment in Multiple Myeloma 以PPARγ/RXRα为靶点治疗多发性骨髓瘤的实验研究
Objective To study the alteration of retinoid X receptor α ( RXR α) with the treatment of tazarotene in active psoriasis vulgaris and investigate the mechanism. 目的研究他扎罗汀治疗进行期寻常型银屑病前后异维甲酸受体α(RXRα)的变化,并探讨其作用机制。
Inhibition of PPAR γ and RXR agonists on aromatase activity and its mRNA transcriptional level in human ovarian granulosa cells PPARγ和RXR激动剂抑制人卵巢颗粒细胞芳香化酶活性和其mRNA的水平
Advances in studies on selective RXR ligands 选择性RXR配体的研究进展
Inhibition of RXR α transcriptional activity by TPA was detected by CAT assay. 用CAT分析检测RXRα转录活性的抑制。
Regulatory Function of PPAR γ-LXR α/ RXR α-ABC1/ CYP7A1 Pathway in Cholesterol Reverse Transportation and Metabolism PPARγ-LXRα/RXRα-ABC1/CYP7A1途径在胆固醇逆向转运和胆固醇代谢中的调控作用研究
AtRA exerts its effects by binding the retinoic acid receptor ( RAR) and retinoid X receptor ( RXR). 己证实atRA通过核内维甲酸受体(RAR)和维甲类X受体(RXR)的激活而起作用。
Objective: To investigate the relation between human spontaneous abortion and mutations in retinoic X receptor α gene in chorionic villi. 目的:探讨人类自然流产与绒毛中维甲酸X受体α(RXRα)基因突变的关系。
Expression and significance of PPAR γ and RXR α in gastric carcinoma 胃癌组织中过氧化物酶体增殖因子活化受体γ和维甲酸受体α的表达及意义
Conclusion Tazarotene upregulates the expression of RXR α and inhibits proliferation and induces apoptosis of keratinocytes through facilitating the binding of RAR γ RXR α in psoriatic epidermis. 结论他扎罗汀通过促进RARγRXRα的结合,上调银屑病表皮基底上层中RXRα的表达,抑制表皮角质形成细胞的增殖并诱导凋亡。
From chronic non atrophic gastritis, chronic atrophic gastritis to gastric carcinoma, expressions of PPAR γ and RXR α showed an ascending tendency. 从慢性胃炎、胃黏膜不典型增生到胃癌,PPARγ和RXRα阳性率呈递增趋势;
Effects of 9-cis retinoic acid on RAR_ α、 RAR_ and RXR_ α transcription in human lung tumor tissue 9-顺维甲酸对人肺癌组织RARα、RARβ及RXRα转录的影响
Initially, atRA activates a heterodimer RAR/ RXR, which further recognizes and binds to retinoic acid receptor response element ( RARE) consensus sequence, thereby activating or repressing target gene transcription. AtRA可激活异二聚体RAR/RXR,后者通过识别和结合维甲酸受体反应元件(RARE),进而引起靶基因的转录激活或转录抑制。
The ligands of the retinoic acid acceptor RXR cannot induce teratogenesis, but they can enhance the teratogenesis of the RAR stimulus. 视黄酸受体RXR的配体无致畸活性,但是可加强RAR激动剂的某些致畸郊应。
Objective To investigate the regulatory effects of peroxisome-proliferator activated receptor γ ( PPAR γ) and retinoid X receptor ( RXR) agonists on the aromatase activity in human ovarian granulosa cells. 目的探讨过氧化酶体增殖物激活受体γ(PPARγ)和维甲类X受体(RXR)激动剂对人卵巢颗粒细胞芳香化酶活性的调节作用。
PPARs form heterodimers with retinoic X receptor bind to PPAR response elements ( PPREs) in the promoter regions of specific target genes to regulate their expressions. PPARs与配体结合后,与视黄酸类受体(RXR)形成异二聚体,然后与所调节基因的启动子上游的过氧化物酶体增殖物反应元件(PPRE)结合而发挥转录调控作用。
The Expression, Regulation and Significance of RXR α in Liver Cancer and Identification of Natural Leads That Induce RXR α to Export Resulting in Extensive Apoptosis RXRα在肝癌细胞中的表达与调控以及一种通过诱导RXRα出核引起细胞凋亡的天然化合物的鉴定
RXR belongs to super family of nuclear hormone receptor, which contains three subtypes(α,β and γ), and regulates many aspects of metazoan life as ligand activated transcriptional factor. 其中RXR属于核激素受体超家族,它包括α、β和γ三种亚型,它们可以作为配体激活型转录因子调控多细胞动物生命的许多方面。
However, it is still uncertain about the role of RXR in the adipocytes differentiating process. In addition to the pathway of RXR acting as a nuclear receptor, whether there is other independent signal pathway regulated by RXR or not still needs to be further studied. 但有关RXR的作用机制尚无定论,除了RXR作为其它核受体的配体这一途径之外,是否还存在独立的RXR调控的信号通路仍是需要深入研究的问题。
RXR inhibitors can lead to severe deformity on amphibian embryos. 研究表明RXR抑制剂能导致两栖类动物胚胎发育的严重畸形。