secretase

1. An experimental study of the effect on α-secretase of rat hippocampal neurons after chronic hypoxic and hypoglycemic culture
   慢性低氧低糖培养影响新生大鼠海马神经元α-分泌酶的实验研究
2. Transcriptional Regulation of Secretase Genes in Alzheimer's Disease
   与老年性痴呆相关分泌酶基因的转录调控
3. Pratic ò said that gamma secretase is present throughout the body and, despite its role in the development of amyloid plaques, plays a significant role in numerous important functions.
   表示，体内γ-分泌酶分布广泛，除了促进淀粉样蛋白斑的生成外，也有许多其他重要的功能。
4. Construction, expression of β secretase prokaryotic expression vector and fusion protein purification
   β分泌酶原核表达载体的构建、表达及融合蛋白纯化
5. Roles of β-secretase in the Pathogenesis of Cerebral Amyloid Angiopathy
   β-分泌酶在脑淀粉样血管病变中的作用研究
6. Design and Synthesis of New γ-Secretase Inhibitors
   新型γ-分泌酶抑制剂的设计与合成
7. Amyloid β secretase gene and the risk for Alzheimer's disease
   阿尔茨海默病与淀粉样β分泌酶基因的相关性研究
8. Objective To investigate the effects of Chinese herb compound Shen-wu capsule on the metabolism of β-amyloid ( A β) and β-and γ-secretase in β-amyloid precursor protein ( APP) transgenic mice.
   目的观察中药新复方参乌胶囊对β-淀粉样肽前体蛋白（APP）转基因小鼠脑内β-淀粉样肽（Aβ）代谢及β-和γ-分泌酶的影响。
9. Recent progress in understanding the molecular and cellular pathophysiology of Alzheimer's disease has suggested possible pharmacological interventions, such as treatment with secretase inhibitors, transition metal chelators, HMG-CoA reductase inhibitors and amyloid-β immunization.
   随着对AD分子和细胞病理生理的进一步了解，又发展了医一些新的治疗方法，如分泌酶抑制剂、过渡金属元素螯合剂、HMGCoA还原酶抑制剂和β淀粉样蛋白疫苗等。
10. Aim To discuss in depth the synthesis of hydroxyethylene dipeptide-based β-secretase inhibitors;
    目的深入探讨基于羟基亚乙基二肽的β-分泌酶抑制剂的合成方法。
11. Objective: To establish an assay, based on Gal4/ vp16-UAS and Dual-Luciferase reporter gene, for detecting the activity of γ-secretase in the proteolytic processing of precursor protein.
    目的：确立基于Gal4/vp16-UAS和双荧光素酶报告基因系统检测γ-分泌酶切割淀粉样前体蛋白活性的方法。
12. A screen assay of β-secretase inhibitors in vitro
    β分泌酶抑制剂体外筛选模型的构建与验证
13. Conclusion A screen assay of β-secretase inhibitors was successfully constructed and can be used to screen natural products.
    结论成功构建了β分泌酶抑制剂筛选模型并用于中草药提取物活性筛选。
14. In recent years, studies have focused on understanding the generation of A β peptides by the α-, β-and γ-secretase activity on APP, as cause and progression of both familial and sporadic AD ( FAD and SAD).
    近年来很多研究都集中在α、β和γ-分泌酶对APP的作用和Aβ生成的影响上，以及家族性ADFAD和散发性ADSAD的发病原因和进程的研究。
15. Pharmacophore Model Construction of γ-secretase Inhibitor
    γ-分泌酶抑制剂的药效团模型构建
16. The progress in the search of β-secretase inhibitors is reviewed in this article.
    该文对β-分泌酶抑制剂的研究进展进行了综述。
17. γ-secretase consists of four components PS, Aph-1, NCT and Pen-2.Researching progress about this enzyme is slowly and its structure and function are not entirely understood by far because of its high molecular weight and complicated complex structure.
    γ分泌酶由四种组分PS、Aph-1、NCT及Pen-2构成，由于该酶的相对分子质量巨大以及结构复杂，所以研究进展比较缓慢，其结构与功能至今仍未完全揭示。
18. A drug target for Alzheimers disease: β-secretase
    治疗阿尔采末病的药物靶点：β-分泌酶
19. Therapeutic Potential of α-Secretase in Alzheimer's Disease
    α分泌酶在阿尔茨海默病治疗中的作用
20. Promising drugs to treat Alzheimers disease& γ-secretase inhibitors
    AD治疗新药物&γ-分泌酶抑制剂
21. Applying Gal4/ VP16-UAS and Dual-Luciferase reporter gene system to detecting the activity of γ-secretase
    利用Gal4/VP16-UAS和双荧光素酶报告基因系统检测γ-分泌酶活性
22. The selective inhibition of γ-secretase is a challenge in the development of anti-AD drugs.
    选择性抑制γ-分泌酶的活性是抗AD药物研发中面临的一大挑战。
23. To study the effect of γ-secretase inhibitors on ovarian cancer cell growth, proliferation, adhesion, invasion and migration activity in vitro, and its effects on cell cycle distribution, and to explore its mechanism.
    初步研究γ-分泌酶抑制剂对人卵巢癌细胞的生长、增殖、黏附、侵袭及迁移活性的影响，以及其对细胞周期分布的影响，并探讨其作用机制。
24. Furthermore, activation of CREB by forskolin treatment dramatically promoted the expression of PEN-2 mRNA and protein, but not the expression of the other three γ-secretase components.
    进一步的研究表明，由forskolin激活的CREB显著地促进PEN-2mRNA和蛋白质的表达，而对γ-分泌酶的其他组分没有影响。
25. This conclusion can be also demonstrated in γ secretase inhibitor treatment experiment.
    这一作用在γ分泌酶抑制剂的处理结果中得到了证实。
26. 【 Conclusion 】 1. γ-secretase inhibitors can inhibit cell growth and proliferation of A2780.
    【结论】1.γ-分泌酶抑制剂能够抑制A2780细胞的生长及增殖。
27. Cloning experiment presumed that γ-secretase inhibitors can inhibit the proliferation of A2780 cells, and the cell colony formation rate decreased ( p 0.001). 4.
    γ-分泌酶抑制剂能抑制A2780细胞的增殖，使细胞克隆形成率下降（p0.001）。
28. Inhibition of γ-secretase has proven to be a better target for drug discovery.
    随后大量研究证明抑制γ-分泌酶是一个理想的药物发现靶点。

noun

1. a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's)