Time-dependent Inhibitory Effect and Subcellular Distribution of Sequence-specific HER-2/ neu Phosphorothioate Antisense Oligodeoxynucleotides HER-2/neu反义寡核苷酸对靶基因抑制作用的时相变化与微观分布研究
Gold Nanoparticle Based Chemiluminescent Immunoassay and Sequence-Specific DNA Detection 基于金纳米微粒的化学发光免疫分析和特定序列DNA分析
The back-exchange process is actually complex and deserving of analysis in a sequence-specific manner. 返交换实际上很复杂,需要进行序列特异性的分析。
Reversal of Leukemia Multidrug Resistance by Sequence-Specific Short Hairpin RNA 序列特异性短发夹状RNA逆转白血病多药耐药性研究
RNA interference ( RNAi), an evolutionary highly conserved process of posttranscriptional gene silencing, can be triggered by small interfering RNAs ( siRNAs) that mediate sequence-specific mRNA degradation. RNA干扰(RNAi)是指生物体内由小干扰RNA(siRNAs)介导的具有高度特异性,只降解与之序列相应的单个内源基因mRNA的,在进化上高度保守的转录后基因沉默现象。
Changes in the genotype polymorphism of TNF α and TGF β were detected with sequence-specific primer polymerase chain reaction ( PCR). 采用顺序特异性引物聚合酶链反应方法检测肿瘤坏死因子α和转化生长因子β基因型别多态性变化。
Functional Gold Nanoparticle-enhanced Electrochemical Determination of DNA Hybridization and Sequence-specific Analysis 功能化纳米金增强的DNA电化学检测和序列分析
RNAi silences gene in a sequence-specific manner through the actions of small fragment of double-stranded RNAs. RNAi的机制是通过一段小片段双链RNA的作用序列特异性地使一段目的基因失活。
Posttranscriptional gene silencing ( PTGS) in plants is a form of RNA silencing by which target RNA is degraded in a sequence-specific manner. 植物中的转录后基因沉默(PTGS)是RNA沉默的一种形式,通过PTGS能对目标RNA进行特异性降解。
These inhibitive effect of siRNA on HBV was dose-dependent and sequence-specific. siRNA抑制作用呈剂量依赖性和序列特异性。
Being a highly conserved and sequence-specific RNA degradation system in eukaryotic, RNA silencing is both a fundamental biological issue and a highly promising application upon the control of gene expression or the analysis of gene function. RNA沉默是真核生物的一种高度保守的和序列特异的RNA降解系统,它不但是基础生物学领域的研究热点,同时在调节基因表达或研究基因功能方面也是非常有前景的。
Control DNA samples that genotypes known were used to confirm the sensitivity and specificity of each sequence-specific primer. 引物的特异性和灵敏度采用基因型已知的质控DNA进行验证。
Double-stranded RNA-mediated RNA interference ( RNAi) is one of the process of sequence-specific post-transcriptional gene silencing. RNA干涉(RNAi)是双链RNA介导的转录后基因沉默作用的重要机制之一。
Screening out CpG immunostimulatory sequence-specific DNA-binding proteins with Yeast-one-hybrid system 应用酵母单杂交系统筛选CpG免疫激活序列的特异性结合蛋白
RNA interference ( RNAi), a sequence-specific RNA degradation mechanism mediated by small interfering RNA ( siRNA), can be used not only as a research tool but also as a therapeutic strategy for viral infection. RNA干扰(RNAi)是一种由小干扰RNA(siRNA)介导的靶序列特异性RNA降解机制,现在它不仅被当作一种研究工具,还可以用作一种抑制病毒感染的基因治疗策略。
RNA silencing is an anti-viral defense mechanism involved in degradation of exogenous nucleic acid via sequence-specific interaction. RNA沉默(RNAsilencing)是一种依赖核酸序列特异性的抗病毒防御机制。
We herein propose an ultra-sensitive, fast, simple and convenient-operated method for sequence-specific polynucleotides detection. 因此,作者提出了一种灵敏度很高,而且快速、简单、操作方便的核酸序列特异性检测方法。
Gene chip was a basic chip which had a number of oligonucleotide probes, each point containing complementary linked with the sequence-specific probe and the target gene. 基因芯片是一种点有若干寡核苷酸探针的基片,每个点都含有序列特异的探针和目标基因互补结合。
Transcription factors, also known as sequence-specific DNA binding proteins, contain one or more DNA binding domains ( DBDs). 转录因子,也被称为序列特异性DNA结合蛋白,含有一个或多个DNA结合结构域(DBDs)。
RNAi is the sequence-specific gene silencing induced by double-stranded RNA ( dsRNA). 它是由双股RNA诱导的序列特异性基因沉默机制。
These 19-31 nt non-coding RNAs work in a sequence-specific manner to facilitate mRNA degradation, translational inhibition, heterochromatin formation and transposon control, thus leading to gene silencing. 这些19&31nt的非编码RNA以序列特异性的方式使得mRNA降解、翻译抑制、异染色质形成和转座子控制,进而导致基因沉默。
Its molecular function is described as: specific RNA polymerase II transcription factor activity; sequence-specific DNA binding; transcription factor activity. 分子功能有:专一的RNA聚合酶Ⅱ转录因子活性,与特定DNA序列结合和转录因子活性。
RNAi technology is a powerful experimental tool in laboratory. Using of homologous double-stranded RNA ( dsRNA)-induced sequence-specific silencing of target genes, it can rapidly block gene activity. RNA干涉(RNAi)技术在实验室中是一种强大的实验工具,它是利用具有同源性的双链RNA(dsRNA)诱导特异性的目标基因沉默,迅速降低基因表达水平。
RNA interference ( RNAi) is a sequence-specific, post-transcriptional gene silencing mechanism. Now RNAi has been adopted as a functional genomics tool and a gene therapy approach. RNA干扰(RNAinterference,RNAi)是一种序列特异性、转录后基因沉默的机制,目前,RNAi已应用于基因功能、疾病治疗的研究。