Pharmacokinetics and bioequivalence of sibutramine dripping pills in healthy volunteers Determination of Sibutramine Hydrochloride in Chinese Traditional Patented Medicine and Health Supplements by Ion Pair RP/ HPLC 盐酸西布曲明滴丸人体药动学和生物等效性反相离子对高效液相色谱法对中成药与保健食品中盐酸西布曲明的测定
Study on the characteristics of metabolic syndrome model in mice and therapeutic effect of sibutramine 小鼠代谢综合征模型的特征及西布曲明的治疗作用研究
Treatment with orlistat is associated with frequent gastrointestinal side effects, sibutramine may raise blood pressure and heart rate, and rimonabant may increase the risk of mood disorders. 奥利斯特治疗伴随有频繁的胃肠道副作用,西布曲明可能会带来血压和心率的升高,利莫那班则可能增加心理障碍的发病率。
The sibutramine dose in each capsule corresponded to twice the daily maximum dose of the prescription drug in Germany. 每一粒减肥中药胶囊中西布曲明的含量是其日最大剂量的两倍。
Those who are obese with no heart problems and have not lost weight with diet and exercise are ideal candidates for the drug, also known as sibutramine, he said. 不伴有心脏疾病、通过饮食和运动体重未下降的肥胖者是使用以西布曲明闻名的药物的理想候选者,他说。
The sibutramine was prepared from sibutramine hydrochloride, its resolution was proceeded using D-camphor-10-sulfonic acid. 首先用盐酸西布曲明制备出实验用西布曲明,然后用D-樟脑-10-磺酸进行拆分。
Objective To evaluate the efficacy and safety of sibutramine in simple over weighted and obese subjects. 目的:评价盐酸西布曲明治疗单纯性肥胖患者的疗效与安全性。
Objective: To develop a specific, sensitive and rapid HPLC-MS-MS assay for sibutramine hydrochloride and fenfluramine hydrochloride, and provide a detection method for identification of the two anti-obesity drugs illegally adulterated in traditional Chinese medicine ( TCM) preparations. 目的:建立盐酸西布曲明和盐酸芬氟拉明的液相色谱-质谱联用分析方法,为鉴定中药制剂中非法掺入的这2种减肥药提供检测手段。
Based on derivative reaction, a new derivative fluorescence method is developed for the determination of sibutramine hydrochloride. 通过衍生反应,建立了用荧光光度法测定盐酸西布曲明的新方法。
Efficacy and safety of sibutramine in treatment of patients with overweight and simple obesity 国产西布曲明对超重和单纯性肥胖患者的近期疗效及安全性分析
Abnormalities of left ventricular structure and function existed in obese patients were ameliorated with sibutramine treatment. The improvement seems to be related to weight loss due to sibutramine. 单纯性肥胖患者早期存在左心室结构和功能的异常,西布曲明治疗3个月后患者的左心室结构和功能有所改善,可能与西布曲明减轻体重有关。
Effect of sex on weight loss with sibutramine 探讨性别对西布曲明片减肥疗效的影响
Level of Free Fat Acid Could be Decreased in Obese Subjects after 6 Months 'Treatment with Sibutramine 西布曲明治疗6个月可降低肥胖患者血清游离脂肪酸水平
Conclusion: ① This three schemes mentioned above are effective for weight reduction, among them, the effect is best by using sibutramine and metformin together, which is second~ best by using sibutramine simply and tertius by metformin. 结论:①三种治疗方案对减肥均有疗效,其中西布曲明和二甲双胍联合治疗疗效最佳,单用西布曲明疗效次之,而单用二甲双胍疗效最差。
Conclusion Sibutramine has the effect of losing weight, reducing body lipid and improving glucose metabolism in obese patients. 结论西布曲明具有使肥胖症患者减轻体重、减少体脂及改善糖代谢的作用。
Efficacy and safety of sibutramine in simple over-weighted and obese subjects ·安全方面。盐酸西布曲明治疗单纯性肥胖的疗效与安全性
CONCLUSION: Sibutramine capsule has a significant effect in reducing body mass, and effectively ameliorating blood lipids, but has no obvious influence on insulin sensitivity index. 结论:盐酸西布曲明胶囊有显著减重效果,并能有效改善血脂,但对胰岛素敏感性指标无明显影响。
Effect of sibutramine on the obesity with metabolic disorder of blood glucose and lipid 西布曲明对肥胖伴糖脂代谢异常的治疗作用
Conclusion: Sibutramine hydrochloride has an anti-body obesity effect and improves cardiac function for the alimentary obesity rats. 结论:盐酸西布曲明灌胃给药对单纯性肥胖大鼠有明显的减肥降脂作用及改善心功能作用。
Sibutramine capsules for treatment of simple obesity 西布曲明胶囊治疗单纯性肥胖
Effect of sibutramine on the ultrasound detected abnormalities of left ventricular structure and function in obese patients 西布曲明对肥胖患者左心室结构与功能超声检测异常的影响
The effects of Xenical and Sibutramine on the risk factors of cardiovascular disease and free testosterone level 减肥药奥利司他和西布曲明对心血管疾病危险因素及游离睾酮水平的影响
Effects on fertility and early embryonic development to implantation of Sibutramine hydrochloride in mice 盐酸西部曲明对小鼠生殖力和着床前后胚胎发育的影响
Objective: To study the change of serum interleukin 6 levels in obese patients and effect of sibutramine on its levels. 目的:观察单纯性肥胖患者血清IL-6水平及西布曲明减重治疗对其的影响。
Objective To evaluate the clinical therapeutic efficacy and safety of sibutramine to simple obesity and compare the effects of sibutramine and placebo on resting metabolic rate. 目的:评价西布曲明治疗单纯性肥胖病的临床疗效和安全性,并比较西布曲明和安慰剂对静息代谢率的影响。
Methods This was a randomized, single-blind, multi-center trial with parallel control groups of sibutramine and placebo. 方法为随机、单盲、多中心、减肥药西布曲明及安慰剂平行对照的临床试验。
Among them, when using DMTA as resolving agent, the salt of non-enantiomer can be facilely precipitated in ethyl acetate. Followed by recrystallization and dissociation, optically pure sibutramine was obtained. 研究表明,用DMTA进行拆分时,在乙酸乙酯中可析出非对映异构体盐,对其进行重结晶和解离后得到光学纯西布曲明。