Effects of sophoricoside and genistein on biological characteristics of osteoblasts 槐角苷及染料木素对成骨细胞生物学特性的影响
Methods We studied the main metabolite of sophoricoside and quantified it in homogenized liver of rats by HPLC. Furthermore, we determined the enzymatic parameters of sophoricoside metabolism in vitro. 方法应用HPLC测定槐苷在大鼠肝匀浆中主要代谢产物的含量,并测定其动力学参数。
Effect of sophoricoside on histomorphology of bone in ovariectomized rats 槐甙对去卵巢大鼠骨量丢失的预防作用
Metabolism of Sophoricoside in Homogenized Liver of Rats 槐苷在大鼠肝匀浆中的代谢
Conclusions: Sophoricoside Capsule can improve BMD and relieve back pain by inhibiting bone resorption. 结论:槐甙胶囊有改善绝经后妇女腰椎骨密度和抑制骨吸收的作用,能明显减轻患者的腰背疼痛。
Studied the contents, Sophoricoside of Sophora fruit, in order to control quality of Sophora fruit and development of new medicine and clinical purpose. 为了进一步对槐角的质量进行控制及临床用药和新药开发奠定物质基础,本试验对槐角苷进行了含量测定研究。
METHODS: Twenty two postmenopausal osteoporosis patients with low density of L1-4 were administered Sophoricoside Capsules, 60 mg per day for 3 months. 方法:22例腰椎(L1,L2,L3,L4)骨密度低于一个标准差以下的绝经后患者入选,每日口服槐甙胶囊60mg,连续3个月。治疗前后检查腰椎和前臂骨密度;
Objective To elucidate the metabolism of sophoricoside in homogenized liver of rats. 目的为阐明槐苷在大鼠肝中的代谢产物及其代谢过程,对槐苷进行体外代谢研究。
Results After incubated 4 h, the total recovery of sophoricoside is more than 78%, and the main metabolite of sophoricoside was genistein. 结果槐苷在大鼠肝匀浆中孵育4h后总回收率大于78%(槐苷+苷元),主要代谢产物为其苷元。
The estrogen-like effect of extract in Pucheng of Weinan and Xunyi of Xianyang is obvious. The two extracts contain more sophoricoside. We can conclude that estrogen-like effects of Fructus Sophorae extract mainly due to the isoflavones. 渭南蒲城组、咸阳旬邑组提取物雌激素样作用表现明显,两提取物中槐角苷含量较高,表明槐角提取物的雌激素样作用主要源于其所含的异黄酮类化合物。
We find that the content of total flavonoids in Fructus Sophorae from different sources has some differences, so is the content of sophoricoside. This may be related to the duration of sunshine, temperature, altitude and drought. 4. 不同来源的槐角样品中总黄酮和槐角苷的含量有一定差异,这可能与日照时间、温度、海拔和干旱等因素有关。