Days after, the treatment with gargarisma metronidazole, the density of spirilla and all kinds of bacilli, which in the periodontal pocket, descended obviously and the number of cocci increased with time extended. 应用甲硝唑含漱剂药后7天,牙周袋内细菌形态观察,螺旋体和各类杆菌致病菌显著减少,相对球菌随用药时间延长而增多。