A new process for preparation the ketolide antibiotic telithromycin by multistep reactions started from clarithromycin is reported. 以克拉霉素为原料,经多步反应制得酮内酯类抗生素泰利霉素。
Telithromycin, which is the representative of ketolides, has come into market in 2001. It shows very good activity against some macrolide-resistant bacteria. 酮内酯中最具代表性的药物泰利霉素已于2001年成功上市,其对包括大环内酯耐药菌在内的革兰氏阳性菌具有良好的抗菌活性。