Repair of thalassemic human β globin mRNA in cultured erythroid cells by antisense RNA 反义RNA对地中海贫血红系细胞β-珠蛋白mRNA异常剪接的纠正作用
Further Studies on β-Globin Genes of a Combined α-, and β-Thalassemic Family 一个α,β地中海贫血复合家系β珠蛋白基因的进一步研究
Our results revealed that the thalassemic red bloodcells were severe damaged by lipid peroxide. 本文结果表明,地贫红细胞易受脂质过氧化损害;
Detection of β-thalassemic mutations by direct genomic sequencing of polymerase chain reaction amplified DNA 聚合酶链式反应扩增DNA直接测序技术基因诊断β&地中海贫血
Results A recombinant plasmid was obtained, which contained LCR and the human thalassemic β 41/ 42 gene in the correct recombinant direction. 结果所构建的重组载体中含人β珠蛋白基因座控制区(LCR)和β41/42基因,测序结果及引入方向正确。
Rapid Prenatal Diagnosis for β-Thalassemic Mutations by Mutant Oligonucleotide Extension Amplification 应用突变引物延伸扩增技术快速产前诊断β地中海贫血基因突变
Objective In order to establish the foundation for in vitro cell and transgenic mouse model, the Human thalassemic gene β 41/ 42 and LCR gene were cloned and sequenced. 目的构建人β地中海贫血突变基因β41/42及具有调控功能的基因座控制区(LCR)重组载体,为该病基因治疗的体外细胞模型和转基因小鼠模型的建立奠定基础。