Result The human tooth germs continued developing and tooth-germ cells ( ameloblast and odontoblast) differentiated into more progressive stage in vitro. 结果人乳牙牙胚在体外培养期间继续发育,牙齿形成细胞(成釉细胞和成牙本质细胞)分化程度进&步提高。
Conclusion Fluoride may inhibit tooth-germ cell proliferation by restraining the expression of Cyclin D1 and PCNA, leading to the abnormal tooth development. 结论F~-可能通过抑制cyClinD1和PCNA的表达引起细胞增殖的抑制,导致牙胚发育异常。