Objective: To synthesize valdecoxib, a COX-2 inhibitor. 目的:合成COX-2抑制剂戊地昔布。
10~ 40 mg · kg-1 · d-1 Valdecoxib increased the apoptosis rate from 19.1% in control group to 23.1%~ 29.1%, and did not affect the distribution of cell cycle. 10~40mg·kg-1·d-1戊地昔布增加肿瘤细胞的凋亡率,从对照组的19.1%增加到23.1%~29.1%。但对细胞周期分布没有影响。
Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery 心脏外科手术后应用COX-2抑制剂(帕瑞考昔和伐地考昔)的并发症
Synthesis of valdecoxib, a COX-2 inhibitor COX-2抑制剂戊地昔布的合成